Michal Sala
Overview
Explore the profile of Michal Sala including associated specialties, affiliations and a list of published articles.
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44
Citations
374
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Recent Articles
1.
Kocek H, Chalupska D, Dejmek M, Dvorakova A, Zgarbova M, Sala M, et al.
RSC Med Chem
. 2024 Sep;
PMID: 39220762
The emergence of SARS-CoV-2, the causative agent of COVID-19, has highlighted the need for advanced antiviral strategies. Targeting the coronaviral methyltransferase nsp14, which is essential for RNA capping, offers a...
2.
Klima M, Dejmek M, Duchoslav V, Eisenreichova A, Sala M, Chalupsky K, et al.
Structure
. 2024 Feb;
32(4):433-439.e4.
PMID: 38325369
The cGAS-STING pathway is a crucial part of innate immunity; it serves to detect DNA in the cytoplasm and to defend against certain cancers, viruses, and bacteria. We designed and...
3.
Misehe M, Sala M, Matousova M, Hercik K, Kocek H, Chalupska D, et al.
Bioorg Med Chem Lett
. 2023 Nov;
97:129567.
PMID: 38008339
In human cells, receptor-interacting protein kinase 2 (RIPK2) is mainly known to mediate downstream enzymatic cascades from the nucleotide-binding oligomerization domain-containing receptors 1 and 2 (NOD1/2), which are regulators of...
4.
Cermakova K, Tao L, Dejmek M, Sala M, Montierth M, Chan Y, et al.
Nucleic Acids Res
. 2023 Nov;
52(1):4-21.
PMID: 37993417
Several cancer core regulatory circuitries (CRCs) depend on the sustained generation of DNA accessibility by SWI/SNF chromatin remodelers. However, the window when SWI/SNF is acutely essential in these settings has...
5.
Misehe M, Matousova M, Dvorakova A, Hercik K, Skach K, Chalupska D, et al.
Eur J Med Chem
. 2023 Aug;
260:115717.
PMID: 37598483
Receptor-interacting protein kinases 2 and 3 (RIPK2 and RIPK3) are considered attractive therapeutic enzyme targets for the treatment of a multitude of inflammatory diseases and cancers. In this study, we...
6.
Stefek M, Chalupska D, Chalupsky K, Zgarbova M, Dvorakova A, Krafcikova P, et al.
ACS Omega
. 2023 Aug;
8(30):27410-27418.
PMID: 37546609
The search for new drugs against COVID-19 and its causative agent, SARS-CoV-2, is one of the major trends in the current medicinal chemistry. Targeting capping machinery could be one of...
7.
Brehova P, Reznickova E, Skach K, Jorda R, Dejmek M, Vojackova V, et al.
J Med Chem
. 2023 Aug;
66(16):11133-11157.
PMID: 37535845
FLT3 kinase is a potential drug target in acute myeloid leukemia (AML). Patients with FLT3 mutations typically have higher relapse rates and worse outcomes than patients without FLT3 mutations. In...
8.
Osifova Z, Sala M, Dracinsky M
ACS Omega
. 2023 Jul;
8(28):25538-25548.
PMID: 37483191
Hydrogen bonding between nucleobases is a crucial noncovalent interaction for life on Earth. Canonical nucleobases form base pairs according to two main geometries: Watson-Crick pairing, which enables the static functions...
9.
Chambers C, Cermakova K, Chan Y, Kurtz K, Wohlan K, Lewis A, et al.
Cancer Res
. 2023 Jan;
83(7):983-996.
PMID: 36662812
Significance: Disruption of PU.1-directed enhancer programs upon SWI/SNF inhibition causes differentiation of AML cells and induces leukopenia of PU.1-dependent B cells and monocytes, revealing the on- and off-tumor effects of...
10.
Blahut J, Radek Stocek J, Sala M, Dracinsky M
J Magn Reson
. 2022 Nov;
345:107334.
PMID: 36410062
The understanding and correct description of intermolecular hydrogen bonds are crucial in the field of multicomponent pharmaceutical solids, such as salts and cocrystals. Solid isonicotinic acid can serve as a...