Michal Sala
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Explore the profile of Michal Sala including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Misehe M, Klima M, Matousova M, Chalupska D, Dejmek M, Sala M, et al.
Bioorg Med Chem Lett
. 2022 Oct;
76:129010.
PMID: 36184029
Novel 4-aminoquinazoline-6-carboxamide derivatives bearing differently substituted aryl or heteroaryl groups at position 7 in the core were rationally designed, synthesized and evaluated for biological activity in vitro as phosphatidylinositol 4-kinase...
12.
Dejmek M, Sala M, Brazdova A, Vanekova L, Smola M, Klima M, et al.
Structure
. 2022 Jun;
30(8):1146-1156.e11.
PMID: 35690061
Stimulator of interferon genes (STING) is an adaptor protein of the cGAS-STING signaling pathway involved in the sensing of cytosolic DNA. It functions as a receptor for cyclic dinucleotides (CDNs)...
13.
Dejmek M, Konkolova E, Eyer L, Strakova P, Svoboda P, Sala M, et al.
Viruses
. 2021 Aug;
13(8).
PMID: 34452451
SARS-CoV-2 has caused an extensive pandemic of COVID-19 all around the world. Key viral enzymes are suitable molecular targets for the development of new antivirals against SARS-CoV-2 which could represent...
14.
The Structure-Based Design of SARS-CoV-2 nsp14 Methyltransferase Ligands Yields Nanomolar Inhibitors
Otava T, Sala M, Li F, Fanfrlik J, Devkota K, Perveen S, et al.
ACS Infect Dis
. 2021 Jun;
7(8):2214-2220.
PMID: 34152728
In this study, we have focused on the structure-based design of the inhibitors of one of the two SARS-CoV-2 methyltransferases (MTases), nsp14. This MTase catalyzes the transfer of the methyl...
15.
Polidarova M, Brehova P, Kaiser M, Smola M, Dracinsky M, Smith J, et al.
J Med Chem
. 2021 May;
64(11):7596-7616.
PMID: 34019405
Cyclic dinucleotides (CDNs) are second messengers that bind to the stimulator of interferon genes (STING) and trigger the expression of type I interferons and proinflammatory cytokines. Here we evaluate the...
16.
Konkolova E, Dejmek M, Hrebabecky H, Sala M, Boserle J, Nencka R, et al.
Antiviral Res
. 2020 Aug;
182:104899.
PMID: 32763313
Remdesivir was shown to inhibit RNA-dependent RNA-polymerases (RdRp) from distinct viral families such as from Filoviridae (Ebola) and Coronaviridae (SARS-CoV, SARS-CoV-2, MERS). In this study, we tested the ability of...
17.
Sala M, Hollinger K, Thomas A, Dash R, Tallon C, Veeravalli V, et al.
J Med Chem
. 2020 Apr;
63(11):6028-6056.
PMID: 32298582
Neutral sphingomyelinase 2 (nSMase2) catalyzes the cleavage of sphingomyelin to phosphorylcholine and ceramide, an essential step in the formation and release of exosomes from cells that is critical for intracellular...
18.
Kopruluoglu C, Dejmek M, Sala M, Ajani H, Hrebabecky H, Fanfrlik J, et al.
J Mol Recognit
. 2020 Mar;
33(8):e2842.
PMID: 32212222
We report on the discovery of norbornyl moiety as a novel structural motif for cyclin-dependent kinase 2 (CDK2) inhibitors which was identified by screening a carbocyclic nucleoside analogue library. Three...
19.
Prochazkova E, Hrebabecky H, Dejmek M, Sala M, Smidkova M, Tloustova E, et al.
Bioorg Med Chem Lett
. 2019 Dec;
30(4):126897.
PMID: 31882298
The nucleoside/nucleotide derived antiviral agents have been the most important components of antiviral therapy used in clinics. Recently, the focus of the medicinal chemists within this exciting research field has...
20.
Radek Stocek J, Bartova K, cechova L, Sala M, Socha O, Janeba Z, et al.
Chem Commun (Camb)
. 2019 Aug;
55(74):11075-11078.
PMID: 31455961
A fast straightforward method for the determination of free energies of modified nucleobase pairing is proposed. The method is based on the nuclear magnetic resonance (NMR) spectroscopy monitoring of conformational...