Michal Galezowski
Overview
Explore the profile of Michal Galezowski including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
146
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0
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Recent Articles
1.
Galezowski M, Fabritius C, Pesonen U, Salo H, Olszak-Plachta M, Czerwinska K, et al.
Bioorg Med Chem Lett
. 2023 Oct;
96:129497.
PMID: 37806499
In this study, we present the discovery and pharmacological characterization of a new series of 6-piperazinyl-7-azaindoles. These compounds demonstrate potent antagonism and selectivity against the 5-HT receptor. Our research primarily...
2.
Heinrich T, Sala-Hojman A, Ferretti R, Petersson C, Minguzzi S, Gondela A, et al.
J Med Chem
. 2021 Aug;
64(16):11904-11933.
PMID: 34382802
Due to increased lactate production during glucose metabolism, tumor cells heavily rely on efficient lactate transport to avoid intracellular lactate accumulation and acidification. Monocarboxylate transporter 4 (MCT4/SLC16A3) is a lactate...
3.
Dziedzic K, Wegrzyn P, Galezowski M, Bonkowska M, Grycuk K, Satala G, et al.
Int Immunopharmacol
. 2021 Apr;
96:107645.
PMID: 33894488
Immunosuppression is one of the main mechanisms facilitating tumor expansion. It may be driven by immune checkpoint protein expression, anti-inflammatory cytokine secretion or enhanced metabolic enzyme production, leading to the...
4.
Harrison D, Boutard N, Brzozka K, Bugaj M, Chmielewski S, Cierpich A, et al.
Bioorg Med Chem Lett
. 2020 Sep;
30(23):127560.
PMID: 32956781
The NLRP3 inflammasome is a component of the innate immune system involved in the production of proinflammatory cytokines. Aberrant activation by a wide range of exogenous and endogenous signals can...
5.
Podkalicka P, Mucha O, Kruczek S, Biela A, Andrysiak K, Stepniewski J, et al.
Biomolecules
. 2020 Jan;
10(1).
PMID: 31963199
Elevated expression of heme oxygenase-1 (HO-1, encoded by ) is observed in various types of tumors. Hence, it is suggested that HO-1 may serve as a potential target in anticancer...
6.
Mucha O, Podkalicka P, Mikulski M, Barwacz S, Andrysiak K, Biela A, et al.
Arch Biochem Biophys
. 2019 Jul;
671:130-142.
PMID: 31276659
Heme oxygenase-1 (HO-1, HMOX1) degrades pro-oxidant heme into carbon monoxide (CO), ferrous ions (Fe) and biliverdin. The enzyme exerts multiple cytoprotective functions associated with the promotion of angiogenesis and counteraction...
7.
Czardybon W, Windak R, Golas A, Galezowski M, Sabiniarz A, Dolata I, et al.
Oncotarget
. 2018 Apr;
9(24):16917-16931.
PMID: 29682194
Fms-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) is one of the most common genetic lesions in acute myeloid leukemia patients (AML). Although FLT3 tyrosine kinase inhibitors initially exhibit clinical...
8.
Bialopiotrowicz E, Gorniak P, Noyszewska-Kania M, Pula B, Makuch-Lasica H, Nowak G, et al.
J Cell Mol Med
. 2018 Apr;
22(7):3548-3559.
PMID: 29665227
Lymph node microenvironment provides chronic lymphocytic leukaemia (CLL) cells with signals promoting their survival and granting resistance to chemotherapeutics. CLL cells overexpress PIM kinases, which regulate apoptosis, cell cycle and...
9.
Szydlowski M, Prochorec-Sobieszek M, Szumera-Cieckiewicz A, Derezinska E, Hoser G, Wasilewska D, et al.
Blood
. 2017 Jul;
130(12):1418-1429.
PMID: 28698206
Reed-Sternberg (RS) cells of classical Hodgkin lymphoma (cHL) express multiple immunoregulatory proteins that shape the cHL microenvironment and allow tumor cells to evade immune surveillance. Expression of certain immunoregulatory proteins...
10.
Fabritius C, Pesonen U, Messinger J, Horvath R, Salo H, Galezowski M, et al.
Bioorg Med Chem Lett
. 2016 Apr;
26(11):2610-5.
PMID: 27117428
A series of 1-Sulfonyl-6-Piperazinyl-7-Azaindoles, showing strong antagonistic activity to 5-HT6 receptor (5-HT6R) was synthesized and characterized. The series was optimized to reduce activity on D2 receptor. Based on the selectivity...