Maciej Mikulski
Overview
Explore the profile of Maciej Mikulski including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
152
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0
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Recent Articles
1.
Zhan Y, Guo J, Yang W, Goncalves C, Rzymski T, Dreas A, et al.
J Clin Invest
. 2024 Apr;
134(8).
PMID: 38618965
No abstract available.
2.
Galezowski M, Fabritius C, Pesonen U, Salo H, Olszak-Plachta M, Czerwinska K, et al.
Bioorg Med Chem Lett
. 2023 Oct;
96:129497.
PMID: 37806499
In this study, we present the discovery and pharmacological characterization of a new series of 6-piperazinyl-7-azaindoles. These compounds demonstrate potent antagonism and selectivity against the 5-HT receptor. Our research primarily...
3.
Heinrich T, Sala-Hojman A, Ferretti R, Petersson C, Minguzzi S, Gondela A, et al.
J Med Chem
. 2021 Aug;
64(16):11904-11933.
PMID: 34382802
Due to increased lactate production during glucose metabolism, tumor cells heavily rely on efficient lactate transport to avoid intracellular lactate accumulation and acidification. Monocarboxylate transporter 4 (MCT4/SLC16A3) is a lactate...
4.
Kasprzyk P, Hunicz J, Rybak A, Geca M, Mikulski M
Sensors (Basel)
. 2020 Nov;
20(22).
PMID: 33238531
The paper investigates the operation of a wideband universal exhaust gas oxygen (UEGO) sensor in a diesel engine under elevated exhaust backpressure. Although UEGO sensors provide the excess air ratio...
5.
Podkalicka P, Mucha O, Kruczek S, Biela A, Andrysiak K, Stepniewski J, et al.
Biomolecules
. 2020 Jan;
10(1).
PMID: 31963199
Elevated expression of heme oxygenase-1 (HO-1, encoded by ) is observed in various types of tumors. Hence, it is suggested that HO-1 may serve as a potential target in anticancer...
6.
Mucha O, Podkalicka P, Mikulski M, Barwacz S, Andrysiak K, Biela A, et al.
Arch Biochem Biophys
. 2019 Jul;
671:130-142.
PMID: 31276659
Heme oxygenase-1 (HO-1, HMOX1) degrades pro-oxidant heme into carbon monoxide (CO), ferrous ions (Fe) and biliverdin. The enzyme exerts multiple cytoprotective functions associated with the promotion of angiogenesis and counteraction...
7.
Boutard N, Bialas A, Sabiniarz A, Guzik P, Banaszak K, Biela A, et al.
Bioorg Med Chem Lett
. 2019 Jan;
29(4):646-653.
PMID: 30626557
In oncology, the "Warburg effect" describes the elevated production of energy by glycolysis in cancer cells. The ubiquitous and hypoxia-induced 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) plays a noteworthy role in the regulation...
8.
Boutard N, Bialas A, Sabiniarz A, Guzik P, Banaszak K, Biela A, et al.
ChemMedChem
. 2018 Nov;
14(1):169-181.
PMID: 30378281
Energy and biomass production in cancer cells are largely supported by aerobic glycolysis in what is called the Warburg effect. The process is regulated by key enzymes, among which phosphofructokinase...
9.
Zhan Y, Guo J, Yang W, Goncalves C, Rzymski T, Dreas A, et al.
J Clin Invest
. 2017 Oct;
127(11):4179-4192.
PMID: 29035277
Melanoma can be stratified into unique subtypes based on distinct pathologies. The acral/mucosal melanoma subtype is characterized by aberrant and constitutive activation of the proto-oncogene receptor tyrosine kinase C-KIT, which...
10.
Rzymski T, Mikula M, Zylkiewicz E, Dreas A, Wiklik K, Golas A, et al.
Oncotarget
. 2017 Apr;
8(20):33779-33795.
PMID: 28422713
Inhibition of oncogenic transcriptional programs is a promising therapeutic strategy. A substituted tricyclic benzimidazole, SEL120-34A, is a novel inhibitor of Cyclin-dependent kinase 8 (CDK8), which regulates transcription by associating with...