Michael W Roe
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Explore the profile of Michael W Roe including associated specialties, affiliations and a list of published articles.
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38
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1456
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Recent Articles
21.
Philipson L, Roe M
Cell Metab
. 2008 Apr;
7(4):280-1.
PMID: 18396130
BAD, a proapoptotic member of the Bcl-2 family of proteins, is regulated by phosphorylation. A recent study (Danial et al., 2008) suggests a phosphorylation-state-dependent bifunctional role of BAD in the...
22.
Barlow C, Kitiphongspattana K, Siddiqui N, Roe M, Mossman B, Lounsbury K
Apoptosis
. 2008 Apr;
13(5):681-92.
PMID: 18392938
Oxidant stress plays a role in the pathogenesis of pulmonary diseases, including fibrotic lung disease and cancer. We previously found that hydrogen peroxide (H2O2) initiates an increase in Ca2+/cAMP-response element...
23.
Fridlyand L, Harbeck M, Roe M, Philipson L
Am J Physiol Cell Physiol
. 2007 Oct;
293(6):C1924-33.
PMID: 17928534
In this report we describe a mathematical model for the regulation of cAMP dynamics in pancreatic beta-cells. Incretin hormones such as glucagon-like peptide 1 (GLP-1) increase cAMP and augment insulin...
24.
Kitiphongspattana K, Khan T, Ishii-Schrade K, Roe M, Philipson L, Gaskins H
Am J Physiol Endocrinol Metab
. 2007 Feb;
292(6):E1543-54.
PMID: 17264231
Higher requirements for disulfide bond formation in professional secretory cells may affect intracellular redox homeostasis, particularly during an endoplasmic reticulum (ER) stress response. To assess this hypothesis, we investigated the...
25.
Barfod E, Moore A, Roe M, Lidofsky S
J Biol Chem
. 2007 Feb;
282(12):8984-93.
PMID: 17264085
Restoration of cell volume in the continued presence of osmotic stimuli is essential, particularly in hepatocytes, which swell upon nutrient uptake. Responses to swelling involve the Ca2+-dependent activation of K+...
26.
Waypa G, Guzy R, Mungai P, Mack M, Marks J, Roe M, et al.
Circ Res
. 2006 Sep;
99(9):970-8.
PMID: 17008601
Mitochondria have been implicated as a potential site of O(2) sensing underlying hypoxic pulmonary vasoconstriction (HPV), but 2 disparate models have been proposed to explain their reaction to hypoxia. One...
27.
Harbeck M, Chepurny O, Nikolaev V, Lohse M, Holz G, Roe M
Sci STKE
. 2006 Sep;
2006(353):pl6.
PMID: 16985238
Understanding the temporal and spatial integration of the Ca2+ and adenosine 3',5'-monophosphate (cAMP) signaling pathways requires concurrent measurements of both second messengers. Here, we describe an optical technique to simultaneously...
28.
Holz G, Kang G, Harbeck M, Roe M, Chepurny O
J Physiol
. 2006 Sep;
577(Pt 1):5-15.
PMID: 16973695
Epac is an acronym for the exchange proteins activated directly by cyclic AMP, a family of cAMP-regulated guanine nucleotide exchange factors (cAMPGEFs) that mediate protein kinase A (PKA)-independent signal transduction...
29.
Roe M, Fiekers J, Philipson L, Bindokas V
Methods Mol Biol
. 2006 May;
319:37-66.
PMID: 16719350
Calcium (Ca2+) is a fundamentally important component of cellular signal transduction. Dynamic changes in the concentration of Ca2+ ([Ca2+]) in the cytoplasm and within organelles are tightly controlled and regulate...
30.
Jacobson D, Cho J, Landa Jr L, Tamarina N, Roe M, Buxbaum J, et al.
Am J Physiol Endocrinol Metab
. 2006 Apr;
291(3):E587-95.
PMID: 16621893
Calcium-binding proteins regulate transcription and secretion of pancreatic islet hormones. Here, we demonstrate neuroendocrine expression of the calcium-binding downstream regulatory element antagonistic modulator (DREAM) and its role in glucose-dependent regulation...