Michael W Roe
Overview
Explore the profile of Michael W Roe including associated specialties, affiliations and a list of published articles.
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Articles
38
Citations
1456
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Recent Articles
31.
Landa Jr L, Harbeck M, Kaihara K, Chepurny O, Kitiphongspattana K, Graf O, et al.
J Biol Chem
. 2005 Jul;
280(35):31294-302.
PMID: 15987680
Ca2+ and cAMP are important second messengers that regulate multiple cellular processes. Although previous studies have suggested direct interactions between Ca2+ and cAMP signaling pathways, the underlying mechanisms remain unresolved....
32.
Kang G, Chepurny O, Rindler M, Collis L, Chepurny Z, Li W, et al.
J Physiol
. 2005 Apr;
566(Pt 1):173-88.
PMID: 15860526
The blood glucose-lowering hormone glucagon-like peptide-1 (GLP-1) stimulates cAMP production, promotes Ca2+ influx, and mobilizes an intracellular source of Ca2+ in pancreatic beta cells. Here we provide evidence that these...
33.
Wang C, Wang Y, Di A, Magnuson M, Ye H, Roe M, et al.
Biochem Biophys Res Commun
. 2005 Apr;
330(4):1073-9.
PMID: 15823553
AMP-activated protein kinase (AMPK) is an important signaling effector that couples cellular metabolism and function. The effects of AMPK activation on pancreatic beta-cell function remain unresolved. We used 5-amino-imidazole carboxamide...
34.
Hara M, Bindokas V, Lopez J, Kaihara K, Landa Jr L, Harbeck M, et al.
Am J Physiol Cell Physiol
. 2004 May;
287(4):C932-8.
PMID: 15163621
The use of biosynthetic fluorescent sensors is an important new approach for imaging Ca(2+) in cells. Genetically encoded indicators based on green fluorescent protein, calmodulin, and fluorescence resonance energy transfer...
35.
Zhou X, Shibusawa N, Naik K, Porras D, Temple K, Ou H, et al.
Nat Med
. 2004 May;
10(6):633-7.
PMID: 15146178
Hepatic gluconeogenesis is essential for maintenance of normal blood glucose concentrations and is regulated by opposing stimulatory (cyclic adenosine monophosphate, cAMP) and inhibitory (insulin) signaling pathways. The cAMP signaling pathway...
36.
Pulver R, Rose-Curtis P, Roe M, Wellman G, Lounsbury K
Circ Res
. 2004 Apr;
94(10):1351-8.
PMID: 15073039
Ca2+-regulated gene transcription is a critical component of arterial responses to injury, hypertension, and tumor-stimulated angiogenesis. The Ca2+/cAMP response element binding protein (CREB), a transcription factor that regulates expression of...
37.
Bindokas V, Kuznetsov A, Sreenan S, Polonsky K, Roe M, Philipson L
J Biol Chem
. 2003 Jan;
278(11):9796-801.
PMID: 12514170
Oxygen free radicals have been implicated in beta-cell dysfunction and apoptosis associated with type 1 and type 2 diabetes mellitus. The roles of free radicals in diabetes have thus far...
38.
Moore A, Roe M, Melnick R, Lidofsky S
J Biol Chem
. 2002 Aug;
277(37):34030-5.
PMID: 12167665
Recovery from swelling of hepatocytes and selected other epithelia is triggered by intracellular Ca(2+) release from the endoplasmic reticulum, which leads to fluid and electrolyte efflux through volume-sensitive K(+) and...