Michael W Roe
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Explore the profile of Michael W Roe including associated specialties, affiliations and a list of published articles.
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38
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1456
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Recent Articles
11.
Kopp R, Leech C, Roe M
J Fluoresc
. 2013 Oct;
24(2):279-84.
PMID: 24151033
Resveratrol, a naturally occurring polyphenol found in some fruits and especially in grapes, has been reported to provide diverse health benefits. Resveratrol's mechanism of action is the subject of many...
12.
Wang R, McGrath B, Kopp R, Roe M, Tang X, Chen G, et al.
J Biol Chem
. 2013 Oct;
288(47):33824-33836.
PMID: 24114838
Protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) (EIF2AK3) is essential for normal development and function of the insulin-secreting β-cell. Although genetic ablation of PERK in β-cells results in permanent...
13.
Brickley D, Agyeman A, Kopp R, Hall B, Harbeck M, Belova L, et al.
J Biol Chem
. 2013 Sep;
288(45):32708-32719.
PMID: 24043625
Serum and glucocorticoid-regulated kinase 1 (SGK1) encodes a phosphatidylinositol 3-kinase-dependent serine/threonine kinase that is rapidly induced in response to cellular stressors and is an important cell survival signal. Previous studies...
14.
Kaihara K, Dickson L, Jacobson D, Tamarina N, Roe M, Philipson L, et al.
Diabetes
. 2013 Jan;
62(5):1527-36.
PMID: 23349500
Acute insulin secretion determines the efficiency of glucose clearance. Moreover, impaired acute insulin release is characteristic of reduced glucose control in the prediabetic state. Incretin hormones, which increase β-cell cAMP,...
15.
Xu Q, Kopp R, Chen Y, Yang J, Roe M, Veenstra R
Am J Physiol Cell Physiol
. 2012 Mar;
302(10):C1548-56.
PMID: 22422398
Calmodulin (CaM) binding sites were recently identified on the cytoplasmic loop (CL) of at least three α-subfamily connexins (Cx43, Cx44, Cx50), while Cx40 does not have this putative CaM binding...
16.
Dzhura I, Chepurny O, Leech C, Roe M, Dzhura E, Xu X, et al.
Islets
. 2011 Apr;
3(3):121-8.
PMID: 21478675
Glucose-stimulated insulin secretion (GSIS) from pancreatic β-cells is potentiated by cAMP-elevating agents, such as the incretin hormone glucagon-like peptide-1 (GLP-1), and cAMP exerts its insulin secretagogue action by activating both...
17.
Kelley G, Chepurny O, Schwede F, Genieser H, Leech C, Roe M, et al.
Islets
. 2010 Nov;
1(3):260-5.
PMID: 21099281
Epac2 is a cAMP-regulated guanine nucleotide exchange factor (cAMP-GEF) that is proposed to mediate stimulatory actions of the second messenger cAMP on mouse islet insulin secretion. Here we have used...
18.
Dzhura I, Chepurny O, Kelley G, Leech C, Roe M, Dzhura E, et al.
J Physiol
. 2010 Nov;
588(Pt 24):4871-89.
PMID: 21041529
Calcium can be mobilized in pancreatic β-cells via a mechanism of Ca(2+)-induced Ca(2+) release (CICR), and cAMP-elevating agents such as exendin-4 facilitate CICR in β-cells by activating both protein kinase...
19.
Wicksteed B, Brissova M, Yan W, Opland D, Plank J, Reinert R, et al.
Diabetes
. 2010 Aug;
59(12):3090-8.
PMID: 20802254
Objective: Conditional gene targeting has been extensively used for in vivo analysis of gene function in β-cell biology. The objective of this study was to examine whether mouse transgenic Cre...
20.
Chepurny O, Kelley G, Dzhura I, Leech C, Roe M, Dzhura E, et al.
Am J Physiol Endocrinol Metab
. 2009 Dec;
298(3):E622-33.
PMID: 20009023
Potential insulin secretagogue properties of an acetoxymethyl ester of a cAMP analog (8-pCPT-2'-O-Me-cAMP-AM) that activates the guanine nucleotide exchange factors Epac1 and Epac2 were assessed using isolated human islets of...