Michael S Dahabieh
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Explore the profile of Michael S Dahabieh including associated specialties, affiliations and a list of published articles.
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Citations
249
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Recent Articles
1.
Ma S, Dahabieh M, Mann T, Zhao S, McDonald B, Song W, et al.
Science
. 2024 Dec;
387(6734):eadj3020.
PMID: 39666821
Exhausted T cells (TEX) in cancer and chronic viral infections undergo metabolic and epigenetic remodeling, impairing their protective capabilities. However, the impact of nutrient metabolism on epigenetic modifications that control...
2.
Oswald B, DeCamp L, Longo J, Dahabieh M, Bunda N, Ma S, et al.
bioRxiv
. 2024 Nov;
PMID: 39605550
Reducing calorie intake without malnutrition limits tumor progression but the underlying mechanisms are poorly understood. Here we show that dietary restriction (DR) suppresses tumor growth by enhancing CD8 T cell-mediated...
3.
Longo J, DeCamp L, Oswald B, Teis R, Reyes-Oliveras A, Dahabieh M, et al.
bioRxiv
. 2024 Oct;
PMID: 39464161
Glucose is essential for T cell proliferation and function, yet its specific metabolic roles remain poorly defined. Here, we identify glycosphingolipid (GSL) biosynthesis as a key pathway fueled by glucose...
4.
Preston S, Dahabieh M, Flores Gonzalez R, Goncalves C, Richard V, Leibovitch M, et al.
Sci Adv
. 2024 Sep;
10(37):eadi7673.
PMID: 39270021
Dysregulation of the mitogen-activated protein kinase interacting kinases 1/2 (MNK1/2)-eukaryotic initiation factor 4E (eIF4E) signaling axis promotes breast cancer progression. MNK1 is known to influence cancer stem cells (CSCs); self-renewing...
5.
Kaymak I, Watson M, Oswald B, Ma S, Johnson B, DeCamp L, et al.
J Exp Med
. 2024 Aug;
221(9).
PMID: 39150482
Coordination of cellular metabolism is essential for optimal T cell responses. Here, we identify cytosolic acetyl-CoA production as an essential metabolic node for CD8 T cell function in vivo. We...
6.
Dahabieh M, DeCamp L, Oswald B, Kitchen-Goosen S, Fu Z, Vos M, et al.
bioRxiv
. 2024 Jul;
PMID: 38979360
The progressive decline of CD8 T cell effector function-also known as terminal exhaustion-is a major contributor to immune evasion in cancer. Yet, the molecular mechanisms that drive CD8 T cell...
7.
Ma E, Dahabieh M, DeCamp L, Kaymak I, Kitchen-Goosen S, Oswald B, et al.
Sci Adv
. 2024 May;
10(22):eadj1431.
PMID: 38809979
Infusion of C-labeled metabolites provides a gold standard for understanding the metabolic processes used by T cells during immune responses in vivo. Through infusion of C-labeled metabolites (glucose, glutamine, and...
8.
Huang F, Cai F, Dahabieh M, Gunawardena K, Talebi A, Dehairs J, et al.
J Clin Invest
. 2023 Aug;
133(20).
PMID: 37616051
Melanomas reprogram their metabolism to rapidly adapt to therapy-induced stress conditions, allowing them to persist and ultimately develop resistance. We report that a subpopulation of melanoma cells tolerate MAPK pathway...
9.
Luda K, Longo J, Kitchen-Goosen S, Duimstra L, Ma E, Watson M, et al.
Immunity
. 2023 Jul;
56(9):2021-2035.e8.
PMID: 37516105
Environmental nutrient availability influences T cell metabolism, impacting T cell function and shaping immune outcomes. Here, we identified ketone bodies (KBs)-including β-hydroxybutyrate (βOHB) and acetoacetate (AcAc)-as essential fuels supporting CD8...
10.
Ma E, Dahabieh M, DeCamp L, Kaymak I, Kitchen-Goosen S, Roy D, et al.
bioRxiv
. 2023 Jun;
PMID: 37333111
Infusion of 13C-labeled metabolites provides a gold-standard for understanding the metabolic processes used by T cells during immune responses . Through infusion of 13C-labeled metabolites (glucose, glutamine, acetate) in ()-infected...