Brandon M Oswald
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Explore the profile of Brandon M Oswald including associated specialties, affiliations and a list of published articles.
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9
Citations
114
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Recent Articles
1.
Ma S, Dahabieh M, Mann T, Zhao S, McDonald B, Song W, et al.
Science
. 2024 Dec;
387(6734):eadj3020.
PMID: 39666821
Exhausted T cells (TEX) in cancer and chronic viral infections undergo metabolic and epigenetic remodeling, impairing their protective capabilities. However, the impact of nutrient metabolism on epigenetic modifications that control...
2.
Oswald B, DeCamp L, Longo J, Dahabieh M, Bunda N, Ma S, et al.
bioRxiv
. 2024 Nov;
PMID: 39605550
Reducing calorie intake without malnutrition limits tumor progression but the underlying mechanisms are poorly understood. Here we show that dietary restriction (DR) suppresses tumor growth by enhancing CD8 T cell-mediated...
3.
Longo J, DeCamp L, Oswald B, Teis R, Reyes-Oliveras A, Dahabieh M, et al.
bioRxiv
. 2024 Oct;
PMID: 39464161
Glucose is essential for T cell proliferation and function, yet its specific metabolic roles remain poorly defined. Here, we identify glycosphingolipid (GSL) biosynthesis as a key pathway fueled by glucose...
4.
Kaymak I, Watson M, Oswald B, Ma S, Johnson B, DeCamp L, et al.
J Exp Med
. 2024 Aug;
221(9).
PMID: 39150482
Coordination of cellular metabolism is essential for optimal T cell responses. Here, we identify cytosolic acetyl-CoA production as an essential metabolic node for CD8 T cell function in vivo. We...
5.
Dahabieh M, DeCamp L, Oswald B, Kitchen-Goosen S, Fu Z, Vos M, et al.
bioRxiv
. 2024 Jul;
PMID: 38979360
The progressive decline of CD8 T cell effector function-also known as terminal exhaustion-is a major contributor to immune evasion in cancer. Yet, the molecular mechanisms that drive CD8 T cell...
6.
Ma E, Dahabieh M, DeCamp L, Kaymak I, Kitchen-Goosen S, Oswald B, et al.
Sci Adv
. 2024 May;
10(22):eadj1431.
PMID: 38809979
Infusion of C-labeled metabolites provides a gold standard for understanding the metabolic processes used by T cells during immune responses in vivo. Through infusion of C-labeled metabolites (glucose, glutamine, and...
7.
Luda K, Longo J, Kitchen-Goosen S, Duimstra L, Ma E, Watson M, et al.
Immunity
. 2023 Jul;
56(9):2021-2035.e8.
PMID: 37516105
Environmental nutrient availability influences T cell metabolism, impacting T cell function and shaping immune outcomes. Here, we identified ketone bodies (KBs)-including β-hydroxybutyrate (βOHB) and acetoacetate (AcAc)-as essential fuels supporting CD8...
8.
Kaymak I, Luda K, Duimstra L, Ma E, Longo J, Dahabieh M, et al.
Cell Metab
. 2022 Aug;
34(9):1298-1311.e6.
PMID: 35981545
How environmental nutrient availability impacts T cell metabolism and function remains poorly understood. Here, we report that the presence of physiologic carbon sources (PCSs) in cell culture medium broadly impacts...
9.
Flores G, Everett J, Boguslawski E, Oswald B, Madaj Z, Beddows I, et al.
Mol Cancer Ther
. 2020 Mar;
19(5):1183-1196.
PMID: 32127464
There is a need to develop novel approaches to improve the balance between efficacy and toxicity for transcription factor-targeted therapies. In this study, we exploit context-dependent differences in RNA polymerase...