Michael S Dahabieh
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Explore the profile of Michael S Dahabieh including associated specialties, affiliations and a list of published articles.
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249
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Recent Articles
11.
Madaj Z, Dahabieh M, Kamalumpundi V, Muhire B, Pettinga J, Siwicki R, et al.
RNA Biol
. 2023 Apr;
20(1):186-197.
PMID: 37095747
Here, we provide an in-depth analysis of the usefulness of single-sample metabolite/RNA extraction for multi-'omics readout. Using pulverized frozen livers of mice injected with lymphocytic choriomeningitis virus (LCMV) or vehicle...
12.
Kaymak I, Luda K, Duimstra L, Ma E, Longo J, Dahabieh M, et al.
Cell Metab
. 2022 Aug;
34(9):1298-1311.e6.
PMID: 35981545
How environmental nutrient availability impacts T cell metabolism and function remains poorly understood. Here, we report that the presence of physiologic carbon sources (PCSs) in cell culture medium broadly impacts...
13.
Dahabieh M, Huang F, Goncalves C, Flores Gonzalez R, Prabhu S, Bolt A, et al.
Autophagy
. 2021 Jun;
18(3):540-558.
PMID: 34074205
Promoting the macroautophagy/autophagy-mediated degradation of specific proteins and organelles can potentially be utilized to induce apoptosis in cancer cells or sensitize tumor cells to therapy. To examine this concept, we...
14.
Yang W, Khoury E, Guo Q, Prabhu S, Emond A, Huang F, et al.
Oncogene
. 2020 Mar;
39(18):3650-3665.
PMID: 32132651
The BRAF mutation occurs in more than 50% of cutaneous melanomas, and results in the constitutive activation of the mitogen-activated protein kinases (MAPK) pathway. MAP kinase-interacting serine/threonine-protein kinase 1 and...
15.
Dahabieh M, Di Pietro E, Jangal M, Goncalves C, Witcher M, Braverman N, et al.
Biochim Biophys Acta Rev Cancer
. 2018 Jul;
1870(1):103-121.
PMID: 30012421
Cancer is irrevocably linked to aberrant metabolic processes. While once considered a vestigial organelle, we now know that peroxisomes play a central role in the metabolism of reactive oxygen species,...
16.
Dahabieh M, Ha Z, Di Pietro E, Nichol J, Bolt A, Goncalves C, et al.
Cell Death Differ
. 2017 Jul;
24(11):1912-1924.
PMID: 28731463
Peroxisomes are a critical rheostat of reactive oxygen species (ROS), yet their role in drug sensitivity and resistance remains unexplored. Gene expression analysis of clinical lymphoma samples suggests that peroxisomes...
17.
Chang C, Bijian K, Qiu D, Su J, Saad A, Dahabieh M, et al.
Oncotarget
. 2017 Apr;
8(19):31199-31214.
PMID: 28415719
Post-translational mechanisms regulating cell-matrix adhesion turnover during cell locomotion are not fully elucidated. In this study, we uncovered an essential role of Y118 site-specific tyrosine phosphorylation of paxillin, an adapter...
18.
Zhan Y, Dahabieh M, Rajakumar A, Dobocan M, MBoutchou M, Goncalves C, et al.
J Invest Dermatol
. 2015 Jan;
135(5):1368-1376.
PMID: 25615552
In eukaryotic cells, the rate-limiting component for cap-dependent mRNA translation is the translation initiation factor eIF4E. eIF4E is overexpressed in a variety of human malignancies, but whether it has a...
19.
Garnier N, Redstone G, Dahabieh M, Nichol J, del Rincon S, Gu Y, et al.
Mol Pharmacol
. 2014 Jan;
85(4):576-85.
PMID: 24431147
Darinaparsin (Dar; ZIO-101; S-dimethylarsino-glutathione) is a promising novel organic arsenical currently undergoing clinical studies in various malignancies. Dar consists of dimethylarsenic conjugated to glutathione (GSH). Dar induces more intracellular arsenic...
20.
Prychyna O, Dahabieh M, Chao J, ONeill M
Biopolymers
. 2009 Jul;
91(11):953-65.
PMID: 19603494
Riboswitch regulation of gene expression requires ligand-mediated RNA folding. From the fluorescence lifetime distribution of bound 2-aminopurine ligand, we resolve three RNA conformers (C(o), C(i), C(c)) of the liganded G-...