Michael J Hunter
Overview
Explore the profile of Michael J Hunter including associated specialties, affiliations and a list of published articles.
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15
Citations
496
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Recent Articles
1.
Neff R, Flinspach M, Gibbs A, Shih A, Minassian N, Liu Y, et al.
J Biol Chem
. 2019 Dec;
295(5):1315-1327.
PMID: 31871053
Pain is a significant public health burden in the United States, and current treatment approaches rely heavily on opioids, which often have limited efficacy and can lead to addiction. In...
2.
Mullican S, Lin-Schmidt X, Chin C, Chavez J, Furman J, Armstrong A, et al.
Nat Med
. 2017 Aug;
23(10):1150-1157.
PMID: 28846097
Growth differentiation factor 15 (GDF15), a distant member of the transforming growth factor (TGF)-β family, is a secreted protein that circulates as a 25-kDa dimer. In humans, elevated GDF15 correlates...
3.
Furman J, Chiu M, Hunter M
AAPS J
. 2014 Oct;
17(1):111-20.
PMID: 25338742
Downstream success in Pharmaceutical Development requires thoughtful molecule design early in the lifetime of any potential therapeutic. Most therapeutic monoclonal antibodies are quite similar with respect to their developability properties....
4.
Ye H, Housden J, Hunter M, Sabban S, Helm B
Mol Immunol
. 2013 Oct;
57(2):151-9.
PMID: 24091297
The Cε2 and Cε4 domains are considered as scaffolds, allowing Cε3 domains to assume an appropriate orientation to interact with FcεRI (Wurzburg and Jardetzky, 2002; Hunter et al., 2008). Human/canine...
5.
Minassian N, Gibbs A, Shih A, Liu Y, Neff R, Sutton S, et al.
J Biol Chem
. 2013 Jun;
288(31):22707-20.
PMID: 23760503
Voltage-gated sodium channels (VGSCs) are essential to the normal function of the vertebrate nervous system. Aberrant function of VGSCs underlies a variety of disorders, including epilepsy, arrhythmia, and pain. A...
6.
Edavettal S, Hunter M, Swanson R
Methods Mol Biol
. 2012 Jan;
841:29-47.
PMID: 22222447
Obtaining diffraction quality crystals is frequently an iterative process which traditionally has involved screening large numbers of crystallization conditions. Due to advances in high-throughput gene engineering, recombinant expression, and purification,...
7.
Hunter M, Zhao H, Tuschong L, Bauer Jr T, Burkholder T, Persons D, et al.
Hum Gene Ther
. 2011 Feb;
22(6):689-96.
PMID: 21275758
Children with leukocyte adhesion deficiency type 1 (LAD-1) and dogs with canine LAD (CLAD) develop life-threatening bacterial infections due to mutations in the leukocyte integrin CD18. Here, we compared the...
8.
Hunter M, Tuschong L, Fowler C, Bauer Jr T, Burkholder T, Hickstein D
Mol Ther
. 2010 Sep;
19(1):113-21.
PMID: 20859258
To identify cellular promoters in a self-inactivating (SIN) lentiviral vector that might be beneficial in treating children with leukocyte adhesion deficiency type 1 (LAD-1), we tested lentiviral vectors with human...
9.
Cianchetta G, Stouch T, Yu W, Shi Z, Tari L, Swanson R, et al.
Curr Chem Genomics
. 2010 Jun;
4:19-26.
PMID: 20556201
Trytophan Hydroxylase Type I (TPH1), most abundantly expressed in the gastrointestinal tract, initiates the synthesis of serotonin by catalyzing hydroxylation of tryptophan in the presence of biopterin and oxygen. We...
10.
Hunter M, Iodice M, Pathak A, Street M, Helm B
Mol Immunol
. 2009 Jan;
46(6):1260-5.
PMID: 19135724
A comparison of IgE recognition by cognate receptors expressed on the C2 canine mastocytoma cell line with analogous events in a rat basophilic leukemia cell line transfected with the alpha-chain...