Birgit A Helm
Overview
Explore the profile of Birgit A Helm including associated specialties, affiliations and a list of published articles.
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12
Citations
17
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Recent Articles
1.
Ye H, Housden J, Hunter M, Sabban S, Helm B
Mol Immunol
. 2013 Oct;
57(2):151-9.
PMID: 24091297
The Cε2 and Cε4 domains are considered as scaffolds, allowing Cε3 domains to assume an appropriate orientation to interact with FcεRI (Wurzburg and Jardetzky, 2002; Hunter et al., 2008). Human/canine...
2.
Ye H, Housden J, Hunter M, Sabban S, Helm B
Mol Immunol
. 2013 Oct;
57(2):111-8.
PMID: 24084098
The interaction of immunoglobulin E (IgE) antibodies with the high-affinity receptor (FcεRI) is important in anti-parasitic immunity and plays a central role in allergic responses. It has been shown that...
3.
Rashid A, Housden J, Helm B, Draber P
Mol Immunol
. 2012 Sep;
53(3):270-3.
PMID: 22964482
The high-affinity IgE receptor (FcɛRI) is formed by the IgE-binding α subunit, β subunit and γ subunits homodimer. All three subunits are required for proper expression of the receptor on...
4.
Offermann D, Mckendrick J, Sejberg J, Mo B, Holdom M, Helm B, et al.
J Org Chem
. 2012 Mar;
77(7):3197-214.
PMID: 22397517
The disruption of the human immunolobulin E-high affinity receptor I (IgE-FcεRI) protein-protein interaction (PPI) is a validated strategy for the development of anti asthma therapeutics. Here, we describe the synthesis...
5.
Sadroddiny E, Moir A, Helm B
Cell Biol Int
. 2011 Nov;
36(4):397-401.
PMID: 22122471
A highly reproducible 2D (two-dimensional) map for the proteome and a pattern of protein phosphorylation of high secretory variant of RBL-2H3 cells (RBL-2H3.1) (a model cell in allergy studies) in...
6.
Sadroddiny E, Moir A, Helm B
Iran J Allergy Asthma Immunol
. 2011 Jun;
10(2):73-80.
PMID: 21625015
IgE-mediated cell signaling, induced by cross-linking of high affinity receptor for IgE (FcεRI) in the presence of antigen (Ag), is a well known mechanism described for mast cell activation in...
7.
Rashid A, Iodice M, Carroll K, Housden J, Hunter M, Sabban S, et al.
Mol Immunol
. 2010 Oct;
48(1-3):128-36.
PMID: 20947168
The high-affinity receptor complex for IgE plays a pivotal role in allergic responses since cross-linking of the high-affinity IgE receptor (FcɛRI) on target cells initiates a signaling cascade facilitating release...
8.
Pathak A, Helm B
Cell Biol Int
. 2009 Dec;
34(4):353-9.
PMID: 20001954
Allergen-mediated cross-linking of the high-affinity receptor for IgE on mast cells triggers the release of diverse preformed and de novo synthesized immunoregulatory mediators that further the allergic response. A proteomic...
9.
Hunter M, Iodice M, Pathak A, Street M, Helm B
Mol Immunol
. 2009 Jan;
46(6):1260-5.
PMID: 19135724
A comparison of IgE recognition by cognate receptors expressed on the C2 canine mastocytoma cell line with analogous events in a rat basophilic leukemia cell line transfected with the alpha-chain...
10.
Hunter M, Vratimos A, Housden J, Helm B
Mol Immunol
. 2008 Jan;
45(8):2262-8.
PMID: 18187193
Identification of the domain(s) of canine IgE that interact with Fc epsilon RI alpha may lead to novel therapeutic intervention strategies that inhibit the ability of canine IgE to engage...