Leslie W Tari
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Explore the profile of Leslie W Tari including associated specialties, affiliations and a list of published articles.
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25
Citations
580
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Recent Articles
1.
Tari L, Li X, Trzoss M, Bensen D, Chen Z, Lam T, et al.
PLoS One
. 2014 Jan;
8(12):e84409.
PMID: 24386374
Increasing resistance to every major class of antibiotics and a dearth of novel classes of antibacterial agents in development pipelines has created a dwindling reservoir of treatment options for serious...
2.
Tari L, Trzoss M, Bensen D, Li X, Chen Z, Lam T, et al.
Bioorg Med Chem Lett
. 2013 Jan;
23(5):1529-36.
PMID: 23352267
The bacterial topoisomerases DNA gyrase (GyrB) and topoisomerase IV (ParE) are essential enzymes that control the topological state of DNA during replication. The high degree of conservation in the ATP-binding...
3.
Trzoss M, Bensen D, Li X, Chen Z, Lam T, Zhang J, et al.
Bioorg Med Chem Lett
. 2013 Jan;
23(5):1537-43.
PMID: 23294697
The structurally related bacterial topoisomerases DNA gyrase (GyrB) and topoisomerase IV (ParE) have long been recognized as prime candidates for the development of broad spectrum antibacterial agents. However, GyrB/ParE targeting...
4.
Tari L
Methods Mol Biol
. 2012 Jan;
841:251-66.
PMID: 22222456
Water plays a crucial role in the mediation of protein-ligand interactions, as underscored by the fact that most X-ray crystal structures (of sufficient resolution) of protein-ligand complexes possess water molecules...
5.
Tari L
Methods Mol Biol
. 2012 Jan;
841:1-27.
PMID: 22222446
Access to detailed three-dimensional structural information on protein drug targets can streamline many aspects of drug discovery, from target selection and target product profile determination, to the discovery of novel...
6.
Cianchetta G, Stouch T, Yu W, Shi Z, Tari L, Swanson R, et al.
Curr Chem Genomics
. 2010 Jun;
4:19-26.
PMID: 20556201
Trytophan Hydroxylase Type I (TPH1), most abundantly expressed in the gastrointestinal tract, initiates the synthesis of serotonin by catalyzing hydroxylation of tryptophan in the presence of biopterin and oxygen. We...
7.
Bressi J, de Jong R, Wu Y, Jennings A, Brown J, OConnell S, et al.
Bioorg Med Chem Lett
. 2010 Apr;
20(10):3138-41.
PMID: 20392637
A series of N-hydroxy-3-[3-(1-substituted-1H-benzoimidazol-2-yl)-phenyl]-acrylamides (5a-5ab) and N-hydroxy-3-[3-(1,4,5-trisubstituted-1H-imidazol-2-yl)-phenyl]-acrylamides (12a-s) were designed, synthesized, and found to be nanomolar inhibitors of human histone deacetylases. Multiple compounds bearing an N1-piperidine demonstrate EC(50)s of 20-100...
8.
Jessop T, Tarver J, Carlsen M, Xu A, Healy J, Heim-Riether A, et al.
Bioorg Med Chem Lett
. 2009 Oct;
19(23):6784-7.
PMID: 19836232
A series of deoxycytidine kinase inhibitors was simultaneously optimized for potency and PK properties. A co-crystal structure then allowed merging this series with a high throughput screening hit to afford...
9.
Tari L, McRee D, Jennings A
Methods Biochem Anal
. 2009 Feb;
45:107-29.
PMID: 19235293
No abstract available.
10.
Khan A, Shouldice S, Kirby S, Yu R, Tari L, Schryvers A
Biochem J
. 2007 Feb;
404(2):217-25.
PMID: 17313366
The periplasmic iron-binding protein, FbpA (ferric-ion-binding protein A), performs an essential role in iron acquisition from transferrin in Haemophilus influenzae. A series of site-directed mutants in the metal-binding amino acids...