Michael C Ostrowski
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Explore the profile of Michael C Ostrowski including associated specialties, affiliations and a list of published articles.
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115
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5422
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Recent Articles
1.
Pryce B, Oles A, Talbert E, Romeo M, Vaena S, Sharma S, et al.
Cell Rep
. 2024 Oct;
43(11):114925.
PMID: 39475511
Although cancer cachexia is classically characterized as a systemic inflammatory disorder, emerging evidence indicates that weight loss also associates with local tissue inflammation. We queried the regulation of this inflammation...
2.
Spadafora V, Pryce B, Oles A, Talbert E, Romeo M, Vaena S, et al.
BMC Cancer
. 2024 Apr;
24(1):414.
PMID: 38570770
Background: Pancreatic ductal adenocarcinoma (PDAC) presents with a high mortality rate. Two important features of PDAC contribute to this poor outcome. The first is metastasis which occurs in ~ 80%...
3.
Robinson T, Hamidi T, Counts B, Guttridge D, Ostrowski M, Zimmers T, et al.
Front Immunol
. 2023 Nov;
14:1207746.
PMID: 38022578
The development of cachexia in the setting of cancer or other chronic diseases is a significant detriment for patients. Cachexia is associated with a decreased ability to tolerate therapies, reduction...
4.
Krisanits B, Schuster R, Randise J, Nogueira L, Lane J, Panguluri G, et al.
Breast Cancer Res
. 2023 Oct;
25(1):118.
PMID: 37803429
Background: Advanced glycation end products (AGEs) are reactive metabolites intrinsically linked with modern dietary patterns. Processed foods, and those high in sugar, protein and fat, often contain high levels of...
5.
Akkapeddi P, Hattori T, Khan I, Glasser E, Koide A, Ketavarapu G, et al.
Proc Natl Acad Sci U S A
. 2023 Jul;
120(28):e2302485120.
PMID: 37399416
The G12D mutation is among the most common KRAS mutations associated with cancer, in particular, pancreatic cancer. Here, we have developed monobodies, small synthetic binding proteins, that are selective to...
6.
Shu Y, Gumma N, Hassan F, Branch D, Baer L, Ostrowski M, et al.
J Biol Chem
. 2023 Jun;
299(8):104917.
PMID: 37315788
Although aging is associated with progressive adiposity and a decline in liver function, the underlying molecular mechanisms and metabolic interplay are incompletely understood. Here, we demonstrate that aging induces hepatic...
7.
Pryce B, Wang D, Zimmers T, Ostrowski M, Guttridge D
Cancer Cell
. 2023 Mar;
41(3):581-584.
PMID: 36868225
Advanced cancers often present with the cachexia syndrome that impacts peripheral tissues, leading to involuntary weight loss and reduced prognosis. The central tissues undergoing depletion are skeletal muscle and adipose,...
8.
Han L, Wu Y, Fang K, Sweeney S, Roesner U, Parrish M, et al.
Nat Commun
. 2023 Jan;
14(1):1.
PMID: 36596776
Pancreatic cancer is characterized by abundant desmoplasia, a dense stroma composed of extra-cellular and cellular components, with cancer associated fibroblasts (CAFs) being the major cellular component. However, the tissue(s) of...
9.
Lefler J, MarElia-Bennett C, Thies K, Hildreth 3rd B, Sharma S, Pitarresi J, et al.
Life Sci Alliance
. 2022 Jul;
5(11).
PMID: 35803738
Pancreatic ductal adenocarcinoma (PDAC) is associated with an incredibly dense stroma, which contributes to its recalcitrance to therapy. Cancer-associated fibroblasts (CAFs) are one of the most abundant cell types within...
10.
Wu J, Liu X, Reeser J, Trimboli A, Pecot T, Sizemore G, et al.
Mol Cancer Res
. 2022 May;
20(8):1233-1246.
PMID: 35533313
Implications: Expression of the p53 tumor suppressor in breast cancer tumor stroma regulates tumorigenesis in an oncogene-specific manner, influences the tumor immune landscape, and ultimately impacts patient survival.