Michael C Ostrowski
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Explore the profile of Michael C Ostrowski including associated specialties, affiliations and a list of published articles.
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115
Citations
5422
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Recent Articles
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Lefler J, Seward C, Ostrowski M
Adv Cancer Res
. 2022 Apr;
154:203-226.
PMID: 35459470
Decades of research have concluded that disruptions to Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) have profound effects on cancer progression. However, as our understanding of the tumor...
13.
Han L, Seward C, Leone G, Ostrowski M
Adv Cancer Res
. 2022 Apr;
154:169-201.
PMID: 35459469
Pancreas and breast cancers both contain abundant stromal components within the tumor tissues. A prominent cell type within the stroma is cancer-associated fibroblasts (CAFs). CAFs play critical and complex roles...
14.
Shu Y, Hassan F, Ostrowski M, Mehta K
JCI Insight
. 2021 Oct;
6(19).
PMID: 34622807
The signaling mechanisms by which dietary fat and cholesterol signals regulate central pathways of glucose homeostasis are not completely understood. By using a hepatocyte-specific PKCβ-deficient (PKCβHep-/-) mouse model, we demonstrated...
15.
Rujchanarong D, Lefler J, Saunders J, Pippin S, Spruill L, Bethard J, et al.
Cancers (Basel)
. 2021 Sep;
13(17).
PMID: 34503228
Breast stroma plays a significant role in breast cancer risk and progression yet remains poorly understood. In breast stroma, collagen is the most abundantly expressed protein and its increased deposition...
16.
Thies K, Cole M, Schafer R, Spehar J, Richardson D, Steck S, et al.
Breast Cancer Res
. 2021 Jun;
23(1):65.
PMID: 34118960
Background: Breast cancer (BC) is the most common cancer in women and the leading cause of cancer-associated mortality in women. In particular, triple-negative BC (TNBC) has the highest rate of...
17.
Yin S, Liu L, Brobbey C, Palanisamy V, Ball L, Olsen S, et al.
Nat Commun
. 2021 Jun;
12(1):3444.
PMID: 34103528
AKT is involved in a number of key cellular processes including cell proliferation, apoptosis and metabolism. Hyperactivation of AKT is associated with many pathological conditions, particularly cancers. Emerging evidence indicates...
18.
Khan I, Marelia-Bennet C, Lefler J, Zuberi M, Denbaum E, Koide A, et al.
Small GTPases
. 2021 May;
13(1):114-127.
PMID: 33949915
is the most frequently mutated oncogene in human cancer with nearly ~20% of cancer patients possessing mutations in one of three genes ( or ). However, is mutated in nearly...
19.
Jones C, Sharick J, Colbert S, Shukla V, Zent J, Ostrowski M, et al.
PLoS One
. 2021 Feb;
16(2):e0245653.
PMID: 33534863
Collagen deposition contributes to both high mammographic density and breast cancer progression. Low stromal PTEN expression has been observed in as many as half of breast tumors and is associated...
20.
Shu Y, Hassan F, Coppola V, Baskin K, Han X, Mehta N, et al.
Mol Metab
. 2020 Dec;
44:101133.
PMID: 33271332
Objective: Nonalcoholic hepatic steatosis, also known as fatty liver, is a uniform response of the liver to hyperlipidic-hypercaloric diet intake. However, the post-ingestive signals and mechanistic processes driving hepatic steatosis...