Michael Bula
Overview
Explore the profile of Michael Bula including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
301
Followers
0
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Recent Articles
1.
Vidovic D, Shamsaei B, Schurer S, Kogan P, Chojnacki S, Kouril M, et al.
Mol Cell Proteomics
. 2025 Mar;
:100947.
PMID: 40089066
The Library of Integrated Network-based Cellular Signatures (LINCS), an NIH Common Fund program, has cataloged and analyzed cellular function and molecular activity profiles in response to >80,000 perturbing agents that...
2.
Blanchard J, Akay L, Davila-Velderrain J, von Maydell D, Mathys H, Davidson S, et al.
Nature
. 2024 Dec;
636(8043):E9.
PMID: 39633058
No abstract available.
3.
Trudler D, Ghatak S, Bula M, Parker J, Talantova M, Luevanos M, et al.
Mol Psychiatry
. 2024 Sep;
PMID: 39349966
MEF2C is a critical transcription factor in neurodevelopment, whose loss-of-function mutation in humans results in MEF2C haploinsufficiency syndrome (MHS), a severe form of autism spectrum disorder (ASD)/intellectual disability (ID). Despite...
4.
Mesentier-Louro L, Suhy N, Broekaart D, Bula M, Pereira A, Blanchard J
Methods Mol Biol
. 2023 Jun;
2683:135-151.
PMID: 37300772
The blood-brain barrier (BBB) is a key physiological component of the brain, protecting the brain from peripheral processes and pathogens. The BBB is a dynamic structure that is heavily involved...
5.
Pao P, Seo J, Lee A, Kritskiy O, Patnaik D, Penney J, et al.
Proc Natl Acad Sci U S A
. 2023 Apr;
120(16):e2217864120.
PMID: 37043533
Aberrant activity of cyclin-dependent kinase (Cdk5) has been implicated in various neurodegenerative diseases. This deleterious effect is mediated by pathological cleavage of the Cdk5 activator p35 into the truncated product...
6.
Blanchard J, Akay L, Davila-Velderrain J, von Maydell D, Mathys H, Davidson S, et al.
Nature
. 2022 Nov;
611(7937):769-779.
PMID: 36385529
APOE4 is the strongest genetic risk factor for Alzheimer's disease. However, the effects of APOE4 on the human brain are not fully understood, limiting opportunities to develop targeted therapeutics for...
7.
Dele-Oni D, Christianson K, Egri S, Jacome A, DeRuff K, Mullahoo J, et al.
Sci Data
. 2021 Aug;
8(1):226.
PMID: 34433823
While gene expression profiling has traditionally been the method of choice for large-scale perturbational profiling studies, proteomics has emerged as an effective tool in this context for directly monitoring cellular...
8.
Blanchard J, Bula M, Davila-Velderrain J, Akay L, Zhu L, Frank A, et al.
Nat Med
. 2021 Jan;
27(2):356.
PMID: 33514950
No abstract available.
9.
Blanchard J, Bula M, Davila-Velderrain J, Akay L, Zhu L, Frank A, et al.
Nat Med
. 2020 Jun;
26(6):952-963.
PMID: 32514169
In Alzheimer's disease, amyloid deposits along the brain vasculature lead to a condition known as cerebral amyloid angiopathy (CAA), which impairs blood-brain barrier (BBB) function and accelerates cognitive degeneration. Apolipoprotein...