Hansruedi Mathys
Overview
Explore the profile of Hansruedi Mathys including associated specialties, affiliations and a list of published articles.
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Articles
33
Citations
4171
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Recent Articles
1.
Du J, Shen M, Mathys H, Roeder K
bioRxiv
. 2025 Feb;
PMID: 39975097
Advances in single-cell sequencing and CRISPR technologies have enabled detailed case-control comparisons and experimental perturbations at single-cell resolution. However, uncovering causal relationships in observational genomic data remains challenging due to...
2.
Castanho I, Yeganeh P, Boix C, Morgan S, Mathys H, Prokopenko D, et al.
bioRxiv
. 2025 Jan;
PMID: 39868232
Background: A significant proportion of individuals maintain healthy cognitive function despite having extensive Alzheimer's disease (AD) pathology, known as cognitive resilience. Understanding the molecular mechanisms that protect these individuals can...
3.
Blanchard J, Akay L, Davila-Velderrain J, von Maydell D, Mathys H, Davidson S, et al.
Nature
. 2024 Dec;
636(8043):E9.
PMID: 39633058
No abstract available.
4.
Iaccarino H, Singer A, Martorell A, Rudenko A, Gao F, Gillingham T, et al.
Nature
. 2024 Nov;
636(8042):E2.
PMID: 39592835
No abstract available.
5.
Arokiaraj C, Leone M, Kleyman M, Chamessian A, Noh M, Phan B, et al.
Cell Rep
. 2024 Oct;
43(11):114876.
PMID: 39453813
Key mechanisms underlying chronic pain occur within the dorsal horn. Genome-wide association studies (GWASs) have identified genetic variants predisposed to chronic pain. However, most of these variants lie within regulatory...
6.
Binette A, Gaiteri C, Wennstrom M, Kumar A, Hristovska I, Spotorno N, et al.
Nat Neurosci
. 2024 Aug;
27(10):1880-1891.
PMID: 39187705
Proteomics can shed light on the dynamic and multifaceted alterations in neurodegenerative disorders like Alzheimer's disease (AD). Combining radioligands measuring β-amyloid (Aβ) plaques and tau tangles with cerebrospinal fluid proteomics,...
7.
Mathys H, Boix C, Akay L, Xia Z, Davila-Velderrain J, Ng A, et al.
Nature
. 2024 Jul;
632(8026):858-868.
PMID: 39048816
Alzheimer's disease is the leading cause of dementia worldwide, but the cellular pathways that underlie its pathological progression across brain regions remain poorly understood. Here we report a single-cell transcriptomic...
8.
von Maydell D, Wright S, Bonner J, Staab C, Spitaleri A, Liu L, et al.
bioRxiv
. 2024 Jul;
PMID: 38979214
Loss-of-function (LoF) variants in the lipid transporter ABCA7 significantly increase the risk of Alzheimer's disease (odds ratio ∼2), yet the pathogenic mechanisms and the neural cell types affected by these...
9.
Sun N, Akay L, Murdock M, Park Y, Galiana-Melendez F, Bubnys A, et al.
Nat Neurosci
. 2023 Nov;
26(12):2251.
PMID: 37907809
No abstract available.
10.
Epigenomic dissection of Alzheimer's disease pinpoints causal variants and reveals epigenome erosion
Xiong X, James B, Boix C, Park Y, Galani K, Victor M, et al.
Cell
. 2023 Sep;
186(20):4422-4437.e21.
PMID: 37774680
Recent work has identified dozens of non-coding loci for Alzheimer's disease (AD) risk, but their mechanisms and AD transcriptional regulatory circuitry are poorly understood. Here, we profile epigenomic and transcriptomic...