Michael B Wheeler
Overview
Explore the profile of Michael B Wheeler including associated specialties, affiliations and a list of published articles.
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Articles
127
Citations
4487
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Recent Articles
1.
Feng J, Shao W, Yang L, Pang J, Ling W, Liu D, et al.
Nutr Diabetes
. 2025 Feb;
15(1):4.
PMID: 39929809
Background: Our mechanistic understanding on metabolic beneficial effects of dietary polyphenols has been hampered for decades due to the lack of functional receptors for those compounds and their extremely low...
2.
Khan S, Van J, Xiangyu Z, Alexeeff S, Razani B, Wheeler M, et al.
Diabetes Metab Res Rev
. 2025 Jan;
41(1):e70027.
PMID: 39810724
Aims: Gestational diabetes mellitus (GDM) poses a significant risk for developing type 2 diabetes mellitus (T2D) and exhibits heterogeneity. However, understanding the link between different types of post-GDM individuals without...
3.
Reduced circulating sphingolipids and activity are linked to T2D risk and impaired insulin secretion
Khan S, Ye W, Van J, Singh I, Rabiee Y, Rodricks K, et al.
Sci Adv
. 2025 Jan;
11(2):eadr1725.
PMID: 39792658
Gestational diabetes mellitus (GDM), a transient form of diabetes that resolves postpartum, is a major risk factor for type 2 diabetes (T2D) in women. While the progression from GDM to...
4.
Izadifar M, Massumi M, Prentice K, Oussenko T, Li B, Elbaz J, et al.
Stem Cell Res Ther
. 2024 Dec;
15(1):486.
PMID: 39696686
Background: Pluripotent cell-derived islet replacement therapy offers promise for treating Type 1 diabetes (T1D), but concerns about uncontrolled cell proliferation and tumorigenicity present significant safety challenges. To address the safety...
5.
Piro A, Luo Y, Zhang Z, Ye W, Kang F, Xie L, et al.
Mol Cell Endocrinol
. 2024 Sep;
594:112376.
PMID: 39321953
Zinc transporter 8 (ZnT8) is highly expressed in pancreatic beta cells, localizes to insulin secretory granules (ISG), and regulates zinc content. ZnT8 gene polymorphisms have revealed a relationship between ZnT8...
6.
β-Cell Insulin Resistance Plays a Causal Role in Fat-Induced β-Cell Dysfunction In Vitro and In Vivo
Ivovic A, Yung J, Oprescu A, Vlavcheski F, Mori Y, Rahman S, et al.
Endocrinology
. 2024 Apr;
165(5).
PMID: 38578954
In the classical insulin target tissues of liver, muscle, and adipose tissue, chronically elevated levels of free fatty acids (FFA) impair insulin signaling. Insulin signaling molecules are also present in...
7.
Wang L, Savani R, Bernabucci M, Lu Y, Singh I, Xu W, et al.
Res Sq
. 2024 Apr;
PMID: 38559032
Central nervous system (CNS) control of metabolism plays a pivotal role in maintaining energy homeostasis. Glucagon-like peptide-1 (GLP-1, encoded by ), secreted by a distinct population of neurons located within...
8.
Wang D, Ju L, Pinguelo A, Kaneshwaran K, Haffey S, Lecker I, et al.
Transl Res
. 2023 Dec;
267:39-53.
PMID: 38042478
General anesthetic drugs cause cognitive deficits that persist after the drugs have been eliminated. Astrocytes may contribute to such cognition-impairing effects through the release of one or more paracrine factors...
9.
Harding J, Vintersten-Nagy K, Yang H, Tang J, Shutova M, Jong E, et al.
Nat Biomed Eng
. 2023 Nov;
8(4):427-442.
PMID: 37996616
The immunogenicity of transplanted allogeneic cells and tissues is a major hurdle to the advancement of cell therapies. Here we show that the overexpression of eight immunomodulatory transgenes (Pdl1, Cd200,...
10.
Van J, Luo Y, Danska J, Dai F, Alexeeff S, Gunderson E, et al.
Metabolism
. 2023 Oct;
149:155695.
PMID: 37802200
Background: Gestational diabetes (GDM) is a distinctive form of diabetes that first presents in pregnancy. While most women return to normoglycemia after delivery, they are nearly ten times more likely...