Michael B Wheeler
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Explore the profile of Michael B Wheeler including associated specialties, affiliations and a list of published articles.
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127
Citations
4487
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Recent Articles
11.
Khan S, Obersterescu A, Gunderson E, Razani B, Wheeler M, Cox B
Bioinformatics
. 2023 Aug;
39(9).
PMID: 37610350
Motivation: The method of genome-wide association studies (GWAS) and metabolomics combined provide an quantitative approach to pinpoint metabolic pathways and genes linked to specific diseases; however, such analyses require both...
12.
Khan S, Rost H, Cox B, Razani B, Alexeeff S, Wheeler M, et al.
medRxiv
. 2023 Jul;
PMID: 37398098
GDM is a strong risk factor for progression to T2D after pregnancy. Although both GDM and T2D exhibit heterogeneity, the link between the distinct heterogeneity of GDM and incident T2D...
13.
Singh I, Wang L, Xia B, Liu J, Tahiri A, El Ouaamari A, et al.
Cell Biosci
. 2022 Oct;
12(1):178.
PMID: 36309763
Background: Central nervous system (CNS) control of metabolism plays a pivotal role in maintaining energy balance. In the brain, Glucagon-like peptide 1 (GLP-1), encoded by the proglucagon 'Gcg' gene, produced...
14.
Zhang Z, Piro A, Allalou A, Alexeeff S, Dai F, Gunderson E, et al.
J Clin Endocrinol Metab
. 2022 Jun;
107(9):2652-2665.
PMID: 35666146
Context: Prolactin is a multifaceted hormone known to regulate lactation. In women with gestational diabetes mellitus (GDM) history, intensive lactation has been associated with lower relative risk of future type...
15.
Zhang Z, Piro A, Dai F, Wheeler M
Front Endocrinol (Lausanne)
. 2022 May;
13:852149.
PMID: 35600586
Objective: Pregnancy is a dynamic state involving multiple metabolic adaptions in various tissues including the endocrine pancreas. However, a detailed characterization of the maternal islet metabolome in relation to islet...
16.
Al Rijjal D, Wheeler M
STAR Protoc
. 2022 Mar;
3(1):101171.
PMID: 35243368
Glucose tolerance test and glucose stimulated insulin secretion are important measures to determine glucose homeostasis and islet function and assess diabetes. Here, we provide a protocol where glucose tolerance test...
17.
Yung J, Yeung L, Ivovic A, Tan Y, Jentz E, Batchuluun B, et al.
Cells
. 2022 Feb;
11(3).
PMID: 35159354
Oxidative stress caused by the exposure of pancreatic ß-cells to high levels of fatty acids impairs insulin secretion. This lipotoxicity is thought to play an important role in ß-cell failure...
18.
Xu J, Jin L, Chen J, Zhang R, Zhang H, Li Y, et al.
Diabetes Res Clin Pract
. 2022 Feb;
185:109235.
PMID: 35131375
Aim: To explore the genetic effects of SLC30A8, IAPP, PCSK1, PCSK2, CPE, PAM and IDE, key genes involved in IAPP processing and degradation pathway on T2DM risk and metabolic traits...
19.
Chalmers J, Dalvi P, Loganathan N, McIlwraith E, Wellhauser L, Nazarians-Armavil A, et al.
Endocrinology
. 2021 Dec;
163(1).
PMID: 34919671
MicroRNAs (miRNAs) expressed in the hypothalamus are capable of regulating energy balance and peripheral metabolism by inhibiting translation of target messenger RNAs (mRNAs). Hypothalamic insulin resistance is known to precede...
20.
Zhang Z, Lai M, Piro A, Alexeeff S, Allalou A, Rost H, et al.
BMC Med
. 2021 Oct;
19(1):241.
PMID: 34620173
Background: Women with a history of gestational diabetes mellitus (GDM) have a 7-fold higher risk of developing type 2 diabetes (T2D). It is estimated that 20-50% of women with GDM...