Alpana Bhattacharjee
Overview
Explore the profile of Alpana Bhattacharjee including associated specialties, affiliations and a list of published articles.
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Articles
23
Citations
809
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Recent Articles
1.
Xu J, Wijesekara N, Regeenes R, Al Rijjal D, Piro A, Song Y, et al.
JCI Insight
. 2021 May;
6(10).
PMID: 34027899
GWAS have shown that the common R325W variant of SLC30A8 (ZnT8) increases the risk of type 2 diabetes (T2D). However, ZnT8 haploinsufficiency is protective against T2D in humans, counterintuitive to...
2.
Untereiner A, Xu J, Bhattacharjee A, Cabrera O, Hu C, Dai F, et al.
Diabetes Obes Metab
. 2020 Jun;
22(11):2021-2031.
PMID: 32558194
Aim: To examine the mechanism of action of γ-aminobutyric acid (GABA) on β-cell proliferation and investigate if co-treatment with Ly49, a novel GABA type A receptor positive allosteric modulator (GABA...
3.
Manialawy Y, Khan S, Bhattacharjee A, Wheeler M
J Biol Chem
. 2020 May;
295(29):9879-9892.
PMID: 32439805
Type 2 diabetes is a chronic metabolic disease characterized by pancreatic β-cell dysfunction and peripheral insulin resistance. Among individuals with type 2 diabetes, ∼30% exhibit hypomagnesemia. Hypomagnesemia has been linked...
4.
Untereiner A, Abdo S, Bhattacharjee A, Gohil H, Pourasgari F, Ibeh N, et al.
FASEB J
. 2018 Dec;
33(3):3968-3984.
PMID: 30509117
γ-Aminobutyric acid (GABA) administration has been shown to increase β-cell mass, leading to a reversal of type 1 diabetes in mice. Whether GABA has any effect on β cells of...
5.
Mohan H, Brandt S, Kim J, Wong F, Lai M, Prentice K, et al.
Diabetes Obes Metab
. 2018 Aug;
21(1):61-72.
PMID: 30062833
Aim: Omega-3 fatty acid ethyl ester supplements, available by prescription, are common in the treatment of dyslipidaemia in humans. Recent studies show that 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid (CMPF), a metabolite formed from...
6.
Batchuluun B, Al Rijjal D, Prentice K, Eversley J, Burdett E, Mohan H, et al.
Diabetes
. 2018 Feb;
67(5):885-897.
PMID: 29436377
Specific circulating metabolites have emerged as important risk factors for the development of diabetes. The acylcarnitines (acylCs) are a family of metabolites known to be elevated in type 2 diabetes...
7.
Dai F, Bhattacharjee A, Liu Y, Batchuluun B, Zhang M, Wang X, et al.
J Biol Chem
. 2015 Aug;
290(41):25045-61.
PMID: 26272612
GLP1 activates its receptor, GLP1R, to enhance insulin secretion. The activation and transduction of GLP1R requires complex interactions with a host of accessory proteins, most of which remain largely unknown....
8.
Han J, Zhang M, Froese S, Dai F, Robitaille M, Bhattacharjee A, et al.
PLoS One
. 2015 Jun;
10(6):e0129226.
PMID: 26075596
Glucagon regulates glucose homeostasis by controlling glycogenolysis and gluconeogenesis in the liver. Exaggerated and dysregulated glucagon secretion can exacerbate hyperglycemia contributing to type 2 diabetes (T2D). Thus, it is important...
9.
Liu Y, Batchuluun B, Ho L, Zhu D, Prentice K, Bhattacharjee A, et al.
J Biol Chem
. 2015 May;
290(30):18757-69.
PMID: 25969539
Zinc plays an essential role in the regulation of pancreatic β cell function, affecting important processes including insulin biosynthesis, glucose-stimulated insulin secretion, and cell viability. Mutations in the zinc efflux...
10.
Zhang M, Robitaille M, Showalter A, Huang X, Liu Y, Bhattacharjee A, et al.
Mol Cell Proteomics
. 2014 Jul;
13(11):3049-62.
PMID: 25044020
Glucagon-like peptide-1 (GLP-1) is an incretin hormone that regulates glucose homeostasis. Because of their direct stimulation of insulin secretion from pancreatic β cells, GLP-1 receptor (GLP-1R) agonists are now important...