Timothy D W Claridge
Overview
Explore the profile of Timothy D W Claridge including associated specialties, affiliations and a list of published articles.
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Articles
135
Citations
2900
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Recent Articles
1.
Koukourakis M, Giatromanolaki A, Zois C, Kalamida D, Pouliliou S, Karagounis I, et al.
Sci Rep
. 2025 Feb;
15(1):4069.
PMID: 39900942
No abstract available.
2.
Gotfredsen H, Hergenhahn J, Duarte F, Claridge T, Anderson H
J Am Chem Soc
. 2024 Aug;
146(36):25232-25244.
PMID: 39186461
Extended π-systems often form supramolecular aggregates, drastically changing their optical and electronic properties. However, aggregation processes can be difficult to characterize or predict. Here, we show that butadiyne-linked 8- and...
3.
Lang P, de Munnik M, Oluwole A, Claridge T, Robinson C, Brem J, et al.
Chembiochem
. 2024 Jul;
25(22):e202400280.
PMID: 39052765
Clavulanic acid is a medicinally important inhibitor of serine β-lactamases (SBLs). We report studies on the mechanisms by which clavulanic acid inhibits representative Ambler class A (TEM-116), C (Escherichia coli...
4.
Kamps J, Zhang D, Claridge T, Schofield C
RSC Med Chem
. 2024 Jul;
15(7):2305-2309.
PMID: 39026654
Rhodanines have been characterised as 'difficult to progress' compounds for medicinal use, though one rhodanine is used for diabetes mellitus treatment and others are in clinical development. Rhodanines can undergo...
5.
Radford-Smith D, Ng T, Yates A, Dunstan I, Claridge T, Anthony D, et al.
J Proteome Res
. 2024 Jun;
23(8):3383-3392.
PMID: 38943617
Tumor necrosis factor (TNF) has well-established roles in neuroinflammatory disorders, but the effect of TNF on the biochemistry of brain cells remains poorly understood. Here, we microinjected TNF into the...
6.
Probert F, Yeo T, Zhou Y, Sealey M, Arora S, Palace J, et al.
Front Immunol
. 2022 Dec;
13:1095038.
PMID: 36582251
[This corrects the article DOI: 10.3389/fimmu.2021.811351.].
7.
Gotfredsen H, Deng J, Van Raden J, Righetto M, Hergenhahn J, Clarke M, et al.
Nat Chem
. 2022 Oct;
14(12):1436-1442.
PMID: 36253501
Natural light-harvesting systems absorb sunlight and transfer its energy to the reaction centre, where it is used for photosynthesis. Synthetic chromophore arrays provide useful models for understanding energy migration in...
8.
Yeo T, Bayuangga H, Augusto-Oliveira M, Sealey M, Claridge T, Tanner R, et al.
J Neuroinflammation
. 2022 Oct;
19(1):252.
PMID: 36210459
Background: Despite widespread searches, there are currently no validated biofluid markers for the detection of subclinical neuroinflammation in multiple sclerosis (MS). The dynamic nature of human metabolism in response to...
9.
Belle R, Kamps J, Poater J, Kumar K, Pieters B, Salah E, et al.
Commun Chem
. 2022 Sep;
5(1).
PMID: 36071790
-Methylation of lysine residues in histones plays an essential role in the regulation of eukaryotic transcription. The 'highest' methylation mark, -trimethyllysine, is specifically recognised by -trimethyllysine binding 'reader' domains, and...
10.
Buchanan C, Gaunt B, Harrison P, Yang Y, Liu J, Khan A, et al.
Science
. 2022 Jun;
377(6604):eabm3125.
PMID: 35737812
Many pathogens exploit host cell-surface glycans. However, precise analyses of glycan ligands binding with heavily modified pathogen proteins can be confounded by overlapping sugar signals and/or compounded with known experimental...