Kirsty S Hewitson
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Explore the profile of Kirsty S Hewitson including associated specialties, affiliations and a list of published articles.
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38
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2554
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Recent Articles
1.
Pfeffer I, Brewitz L, Krojer T, Jensen S, Kochan G, Kershaw N, et al.
Nat Commun
. 2019 Oct;
10(1):4910.
PMID: 31659163
AspH is an endoplasmic reticulum (ER) membrane-anchored 2-oxoglutarate oxygenase whose C-terminal oxygenase and tetratricopeptide repeat (TPR) domains present in the ER lumen. AspH catalyses hydroxylation of asparaginyl- and aspartyl-residues in...
2.
Hewitson K, Vullo D, Scozzafava A, Mastrolorenzo A, Supuran C
J Med Chem
. 2012 Mar;
55(7):3513-20.
PMID: 22424239
A β-carbonic anhydrase (CA, EC 4.2.1.1) from the fungal pathogen Malassezia globosa has been cloned, characterized, and studied for its inhibition with sulfonamides. This enzyme, designated MG-CA, has significant catalytic...
3.
Conejo-Garcia A, McDonough M, Loenarz C, McNeill L, Hewitson K, Ge W, et al.
Bioorg Med Chem Lett
. 2010 Sep;
20(20):6125-8.
PMID: 20822901
Aromatic analogues of the 2-oxoglutarate co-substrate of the hypoxia-inducible factor hydroxylases are shown to bind at the active site iron: Pyridine-2,4-dicarboxylate binds as anticipated with a single molecule chelating the...
4.
Iqbal A, Arunlanantham H, Brown Jr T, Chowdhury R, Clifton I, Kershaw N, et al.
Proteins
. 2009 Dec;
78(6):1398-407.
PMID: 20014241
(3R,5R)-Clavulanic acid (CA) is a clinically important inhibitor of Class A beta-lactamases. Sequence comparisons suggest that orf14 of the clavulanic acid biosynthesis gene cluster encodes for an acetyl transferase (CBG)....
5.
Chowdhury R, McDonough M, Mecinovic J, Loenarz C, Flashman E, Hewitson K, et al.
Structure
. 2009 Jul;
17(7):981-9.
PMID: 19604478
The oxygen-dependent hydroxylation of proline residues in the alpha subunit of hypoxia-inducible transcription factor (HIFalpha) is central to the hypoxic response in animals. Prolyl hydroxylation of HIFalpha increases its binding...
6.
Karkhanina A, Mecinovic J, Musheev M, Krylova S, Petrov A, Hewitson K, et al.
Anal Chem
. 2009 Jun;
81(14):5871-5.
PMID: 19518090
N/O-methylation of DNA can be cytotoxic and mutagenic; therefore, enzymes that reverse DNA methylation are essential for organism survival. Several 2-oxoglutarate-dependent oxygenases and methyltransferases that remove a methyl group from...
7.
Hewitson K, Holmes S, Ehrismann D, Hardy A, Chowdhury R, Schofield C, et al.
J Biol Chem
. 2008 Jul;
283(38):25971-8.
PMID: 18611856
A 2-His-1-carboxylate triad of iron binding residues is present in many non-heme iron oxygenases including the Fe(II) and 2-oxoglutarate (2OG)-dependent dioxygenases. Three variants (D201A, D201E, and D201G) of the iron...
8.
Flashman E, Bagg E, Chowdhury R, Mecinovic J, Loenarz C, McDonough M, et al.
J Biol Chem
. 2007 Dec;
283(7):3808-15.
PMID: 18063574
Hydroxylation of two conserved prolyl residues in the N- and C-terminal oxygen-dependent degradation domains (NODD and CODD) of the alpha-subunit of hypoxia-inducible factor (HIF) signals for its degradation via the...
9.
Hewitson K, Schofield C, Ratcliffe P
Methods Enzymol
. 2007 Nov;
435:25-42.
PMID: 17998047
The adaptation of animals to oxygen availability is mediated by a transcription factor termed hypoxia-inducible factor (HIF). HIF is an alpha (alpha)/beta (beta) heterodimer that binds hypoxia response elements (HREs)...
10.
Gerken T, Girard C, Tung Y, Webby C, Saudek V, Hewitson K, et al.
Science
. 2007 Nov;
318(5855):1469-72.
PMID: 17991826
Variants in the FTO (fat mass and obesity associated) gene are associated with increased body mass index in humans. Here, we show by bioinformatics analysis that FTO shares sequence motifs...