Michael A Frohman
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Explore the profile of Michael A Frohman including associated specialties, affiliations and a list of published articles.
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104
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4263
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Recent Articles
1.
Addassi H, Krga I, Villarreal F, LaComb J, Frohman M, Matsukuma K, et al.
Carcinogenesis
. 2024 Nov;
46(1).
PMID: 39487573
Phospholipase D (PLD) plays a critical role in cancer progression. However, its role in pancreatic cancer remains unclear. Thus, we evaluated the role of PLD1, one of two classical isoforms...
2.
Li F, Wu Z, Gao Y, Bowling F, Franklin J, Hu C, et al.
EMBO J
. 2022 Jul;
41(17):e110698.
PMID: 35844135
The Arf GTPase family is involved in a wide range of cellular regulation including membrane trafficking and organelle-structure assembly. Here, we have generated a proximity interaction network for the Arf...
3.
Lahrouchi N, Postma A, Salazar C, De Laughter D, Tjong F, Piherova L, et al.
J Clin Invest
. 2021 Mar;
131(5).
PMID: 33645542
Congenital heart disease is the most common type of birth defect, accounting for one-third of all congenital anomalies. Using whole-exome sequencing of 2718 patients with congenital heart disease and a...
4.
Bowling F, Frohman M, Airola M
Adv Biol Regul
. 2021 Jan;
79:100783.
PMID: 33495125
Mammalian phospholipase D (PLD) generates phosphatidic acid, a dynamic lipid secondary messenger involved with a broad spectrum of cellular functions including but not limited to metabolism, migration, and exocytosis. As...
5.
Barisano D, Frohman M
Adv Exp Med Biol
. 2020 Jun;
1259:77-87.
PMID: 32578172
The lipid-modifying signal transduction enzyme phospholipase D (PLD) has been proposed to have roles in oncogenic processes for well-on 30 years, with most of the early literature focused on potential...
6.
Bowling F, Salazar C, Bell J, Huq T, Frohman M, Airola M
Nat Chem Biol
. 2020 Mar;
16(4):400-407.
PMID: 32198492
The signal transduction enzyme phospholipase D1 (PLD1) hydrolyzes phosphatidylcholine to generate the lipid second-messenger phosphatidic acid, which plays roles in disease processes such as thrombosis and cancer. PLD1 is directly...
7.
Birey F, Kloc M, Chavali M, Hussein I, Wilson M, Christoffel D, et al.
Neuron
. 2019 Nov;
104(4):825-826.
PMID: 31751546
No abstract available.
8.
Salazar C, Frohman M
Handb Exp Pharmacol
. 2019 Sep;
259:79-88.
PMID: 31541323
Functions for phospholipase D1 and D2 (PLD1 and PLD2), the canonical isoforms of the PLD superfamily in mammals, have been explored using cell biological and animal disease models for two...
9.
Li H, Guo C, Kim-Holzapfel D, Li W, Altshuller Y, Schroeder B, et al.
Biomed Opt Express
. 2019 Feb;
10(1):29-49.
PMID: 30775081
Visualizing diverse anatomical and functional traits that span many spatial scales with high spatio-temporal resolution provides insights into the fundamentals of living organisms. Light-field microscopy (LFM) has recently emerged as...
10.
Ganesan R, Henkels K, Wrenshall L, Kanaho Y, Paolo G, Frohman M, et al.
J Leukoc Biol
. 2018 Apr;
103(5):867-883.
PMID: 29656494
The uptake of cholesterol carried by low-density lipoprotein (LDL) is tightly controlled in the body. Macrophages are not well suited to counteract the cellular consequences of excess cholesterol leading to...