Micah J Niphakis
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Explore the profile of Micah J Niphakis including associated specialties, affiliations and a list of published articles.
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51
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1479
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Recent Articles
21.
Burston J, Mapp P, Sarmad S, Barrett D, Niphakis M, Cravatt B, et al.
Br J Pharmacol
. 2016 Aug;
173(21):3134-3144.
PMID: 27501482
Background And Purpose: Chronic pain is often a symptom of knee osteoarthritis (OA) for which current analgesics are either inadequate or are associated with serious side effects. The endocannabinoid system...
22.
Owens R, Ignatowska-Jankowska B, Mustafa M, Beardsley P, Wiley J, Jali A, et al.
J Pharmacol Exp Ther
. 2016 Jun;
358(2):306-14.
PMID: 27307500
Whereas the inhibition of fatty acid amide hydrolase (FAAH) or monoacylglycerol lipase (MAGL), the respective major hydrolytic enzymes of N-arachidonoyl ethanolamine (AEA) and 2-arachidonoylglycerol (2-AG), elicits no or partial substitution...
23.
Limebeer C, Rock E, Puvanenthirarajah N, Niphakis M, Cravatt B, Parker L
Behav Neurosci
. 2016 Mar;
130(2):261-6.
PMID: 26974857
Anticipatory nausea (AN) is a conditioned nausea reaction experienced by chemotherapy patients upon returning to the clinic. Currently, there are no specific treatments for this phenomenon, with the classic antiemetic...
24.
Wilkerson J, Niphakis M, Grim T, Mustafa M, Abdullah R, Poklis J, et al.
J Pharmacol Exp Ther
. 2016 Jan;
357(1):145-56.
PMID: 26791602
Serious clinical liabilities associated with the prescription of opiates for pain control include constipation, respiratory depression, pruritus, tolerance, abuse, and addiction. A recognized strategy to circumvent these side effects is...
25.
Buczynski M, Herman M, Hsu K, Natividad L, Irimia C, Polis I, et al.
Proc Natl Acad Sci U S A
. 2016 Jan;
113(4):1086-91.
PMID: 26755579
Chronic nicotine exposure (CNE) alters synaptic transmission in the ventral tegmental area (VTA) in a manner that enhances dopaminergic signaling and promotes nicotine use. The present experiments identify a correlation...
26.
Wills K, Petrie G, Millett G, Limebeer C, Rock E, Niphakis M, et al.
Neuropsychopharmacology
. 2015 Dec;
41(7):1865-73.
PMID: 26647976
Both CB1 receptor antagonism and agonism, in particular by 2-arachidonyl glycerol (2-AG), have been shown to reduce somatic symptoms of morphine withdrawal (MWD). Here we evaluated the effects of both...
27.
Sticht M, Limebeer C, Rafla B, Abdullah R, Poklis J, Ho W, et al.
Neuropharmacology
. 2015 Nov;
102:92-102.
PMID: 26541329
Cannabinoid (CB) agonists suppress nausea in humans and animal models; yet, their underlying neural substrates remain largely unknown. Evidence suggests that the visceral insular cortex (VIC) plays a critical role...
28.
Rock E, Limebeer C, Ward J, Cohen A, Grove K, Niphakis M, et al.
Psychopharmacology (Berl)
. 2015 Aug;
232(20):3841-8.
PMID: 26297326
Rationale: Fatty acid amide hydrolase (FAAH) inhibition elevates anandamide (AEA), which acts on cannabinoid (CB1 and CB2) receptors, as well as N-palmitoylethanolamide (PEA) and N-oleoylethanolamine (OEA), which act on peroxisome...
29.
Cognetta 3rd A, Niphakis M, Lee H, Martini M, Hulce J, Cravatt B
Chem Biol
. 2015 Jun;
22(7):928-37.
PMID: 26120000
Serine hydrolase inhibitors, which facilitate enzyme function assignment and are used to treat a range of human disorders, often act by an irreversible mechanism that involves covalent modification of the...
30.
Niphakis M, Lum K, Cognetta 3rd A, Correia B, Ichu T, Olucha J, et al.
Cell
. 2015 Jun;
161(7):1668-80.
PMID: 26091042
Lipids play central roles in physiology and disease, where their structural, metabolic, and signaling functions often arise from interactions with proteins. Here, we describe a set of lipid-based chemical proteomic...