Micah J Niphakis
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Explore the profile of Micah J Niphakis including associated specialties, affiliations and a list of published articles.
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51
Citations
1479
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Recent Articles
11.
Remsberg J, Suciu R, Zambetti N, Hanigan T, Firestone A, Inguva A, et al.
Nat Chem Biol
. 2021 Apr;
17(8):856-864.
PMID: 33927411
Multiple Ras proteins, including N-Ras, depend on a palmitoylation/depalmitoylation cycle to regulate their subcellular trafficking and oncogenicity. General lipase inhibitors such as Palmostatin M (Palm M) block N-Ras depalmitoylation, but...
12.
Mizrak D, Bayin N, Yuan J, Liu Z, Suciu R, Niphakis M, et al.
Cell Rep
. 2020 Jun;
31(12):107805.
PMID: 32579931
In the adult ventricular-subventricular zone (V-SVZ), neural stem cells (NSCs) generate new olfactory bulb (OB) neurons and glia throughout life. To map adult neuronal lineage progression, we profiled >56,000 V-SVZ...
13.
Ertunc M, Kok B, Parsons W, Wang J, Tan D, Donaldson C, et al.
J Biol Chem
. 2020 Mar;
295(18):5891-5905.
PMID: 32152231
Fatty acid esters of hydroxy fatty acids (FAHFAs) are a newly discovered class of signaling lipids with anti-inflammatory and anti-diabetic properties. However, the endogenous regulation of FAHFAs remains a pressing...
14.
Jacobs I, Xu C, Hermes D, League A, Xu C, Nath B, et al.
J Neuroimmune Pharmacol
. 2019 Aug;
14(4):661-678.
PMID: 31372820
In the era of combined antiretroviral therapy, HIV-1 infected individuals are living longer lives; however, longevity is met with an increasing number of HIV-1 associated neurocognitive disorders (HAND) diagnoses. The...
15.
Reardon H, Herbst R, Henry C, Herbst D, Ngo N, Cisar J, et al.
SLAS Technol
. 2019 Jun;
24(5):489-498.
PMID: 31199699
Accurate measurement of drug-target interactions in vivo is critical for both preclinical development and translation to clinical studies, yet many assays rely on indirect measures such as biomarkers associated with...
16.
Clapper J, Henry C, Niphakis M, Knize A, Coppola A, Simon G, et al.
J Pharmacol Exp Ther
. 2018 Oct;
367(3):494-508.
PMID: 30305428
Monoacylglycerol lipase (MGLL) is the primary degradative enzyme for the endocannabinoid 2-arachidonoylglycerol (2-AG). The first MGLL inhibitors have recently entered clinical development for the treatment of neurologic disorders. To support...
17.
Hermes D, Xu C, Poklis J, Niphakis M, Cravatt B, Mackie K, et al.
Neuropharmacology
. 2018 Aug;
141:55-65.
PMID: 30114402
The HIV-1 transactivator of transcription (Tat) is a neurotoxin involved in the pathogenesis of HIV-1 associated neurocognitive disorders (HAND). The neurotoxic effects of Tat are mediated directly via AMPA/NMDA receptor...
18.
Curry Z, Wilkerson J, Bagdas D, Kyte S, Patel N, Donvito G, et al.
J Pharmacol Exp Ther
. 2018 Mar;
366(1):169-183.
PMID: 29540562
Although paclitaxel effectively treats various cancers, its debilitating peripheral neuropathic pain side effects often persist long after treatment has ended. Therefore, a compelling need exists for the identification of novel...
19.
Owens R, Mustafa M, Ignatowska-Jankowska B, Damaj M, Beardsley P, Wiley J, et al.
Neuropharmacology
. 2017 Jul;
125:80-86.
PMID: 28673548
Substantial challenges exist for investigating the cannabinoid receptor type 1 (CB)-mediated discriminative stimulus effects of the endocannabinoids, 2-arachidonoylglycerol (2-AG) and N-arachidonoylethanolamine (anandamide; AEA), compared with exogenous CB receptor agonists, such...
20.
Wilkerson J, Ghosh S, Mustafa M, Abdullah R, Niphakis M, Cabrera R, et al.
Neuropharmacology
. 2016 Nov;
114:156-167.
PMID: 27890602
Although opioids are highly efficacious analgesics, their abuse potential and other untoward side effects diminish their therapeutic utility. The addition of non-opioid analgesics offers a promising strategy to reduce required...