Kenneth M Lum
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Explore the profile of Kenneth M Lum including associated specialties, affiliations and a list of published articles.
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18
Citations
1054
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Recent Articles
1.
Keller L, Nguyen T, Liu L, Hurysz B, Lakemeyer M, Guerra M, et al.
Nat Chem Biol
. 2023 Jun;
19(12):1469-1479.
PMID: 37349583
Serine hydrolases have important roles in signaling and human metabolism, yet little is known about their functions in gut commensal bacteria. Using bioinformatics and chemoproteomics, we identify serine hydrolases in...
2.
Carvalho L, Ross B, Fehr L, Bolgi O, Wohrle S, Lum K, et al.
Angew Chem Int Ed Engl
. 2022 Sep;
61(47):e202210498.
PMID: 36089535
Dipeptidyl peptidases 8 and 9 (DPP8/9) have gathered interest as drug targets due to their important roles in biological processes like immunity and tumorigenesis. Elucidation of their distinct individual functions...
3.
Onguka O, Babin B, Lakemeyer M, Foe I, Amara N, Terrell S, et al.
Cell Chem Biol
. 2021 May;
28(10):1501-1513.e5.
PMID: 34043961
The intracellular protozoan parasite Toxoplasma gondii must scavenge cholesterol and other lipids from the host to facilitate intracellular growth and replication. Enzymes responsible for neutral lipid synthesis have been identified...
4.
Remsberg J, Suciu R, Zambetti N, Hanigan T, Firestone A, Inguva A, et al.
Nat Chem Biol
. 2021 Apr;
17(8):856-864.
PMID: 33927411
Multiple Ras proteins, including N-Ras, depend on a palmitoylation/depalmitoylation cycle to regulate their subcellular trafficking and oncogenicity. General lipase inhibitors such as Palmostatin M (Palm M) block N-Ras depalmitoylation, but...
5.
Vinogradova E, Zhang X, Remillard D, Lazar D, Suciu R, Wang Y, et al.
Cell
. 2020 Jul;
182(4):1009-1026.e29.
PMID: 32730809
Electrophilic compounds originating from nature or chemical synthesis have profound effects on immune cells. These compounds are thought to act by cysteine modification to alter the functions of immune-relevant proteins;...
6.
Mizrak D, Bayin N, Yuan J, Liu Z, Suciu R, Niphakis M, et al.
Cell Rep
. 2020 Jun;
31(12):107805.
PMID: 32579931
In the adult ventricular-subventricular zone (V-SVZ), neural stem cells (NSCs) generate new olfactory bulb (OB) neurons and glia throughout life. To map adult neuronal lineage progression, we profiled >56,000 V-SVZ...
7.
Carvalho L, Almeida V, Brito J, Lum K, Oliveira T, Guedes R, et al.
ACS Chem Biol
. 2020 Mar;
15(4):878-883.
PMID: 32176480
3-Oxo-β-sultams are four-membered ring ambident electrophiles that can react with nucleophiles either at the carbonyl carbon or at the sulfonyl sulfur atoms, and that have been reported to inhibit serine...
8.
Ertunc M, Kok B, Parsons W, Wang J, Tan D, Donaldson C, et al.
J Biol Chem
. 2020 Mar;
295(18):5891-5905.
PMID: 32152231
Fatty acid esters of hydroxy fatty acids (FAHFAs) are a newly discovered class of signaling lipids with anti-inflammatory and anti-diabetic properties. However, the endogenous regulation of FAHFAs remains a pressing...
9.
Chen A, Lum K, Lara-Gonzalez P, Ogasawara D, Cognetta 3rd A, To A, et al.
Nat Chem Biol
. 2019 Mar;
15(5):453-462.
PMID: 30911178
Phenotypic screening has identified small-molecule modulators of aging, but the mechanism of compound action often remains opaque due to the complexities of mapping protein targets in whole organisms. Here, we...
10.
Tan J, Cognetta Iii A, Diaz D, Lum K, Adachi S, Kundu S, et al.
Nat Commun
. 2017 Nov;
8(1):1760.
PMID: 29170371
Heteroatom-rich organoboron compounds have attracted attention as modulators of enzyme function. Driven by the unmet need to develop chemoselective access to boron chemotypes, we report herein the synthesis of α-...