Miao-Hsueh Chen
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Explore the profile of Miao-Hsueh Chen including associated specialties, affiliations and a list of published articles.
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26
Citations
1577
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Recent Articles
1.
Waterstraat M, Wang Z, Kogiso M, Caballero-Juarez R, Chen M
J Vis Exp
. 2024 Apr;
(205).
PMID: 38619263
Brown adipose tissue (BAT)-mediated thermogenesis plays an important role in the regulation of metabolism, and its morphology and function can be greatly impacted by environmental stimuli in mice and humans....
2.
Shi Y, Zhai H, John S, Shen Y, Ran Y, Hoang G, et al.
Cells
. 2021 Jul;
10(6).
PMID: 34199472
Obesity, a dysregulation of adipose tissue, is a major health risk factor associated with many diseases. Brown adipose tissue (BAT)-mediated thermogenesis can potentially regulate energy expenditure, making it an attractive...
3.
Han Y, Xia G, Srisai D, Meng F, He Y, Ran Y, et al.
Nat Commun
. 2021 Jun;
12(1):3525.
PMID: 34112797
Contrasting to the established role of the hypothalamic agouti-related protein (AgRP) neurons in feeding regulation, the neural circuit and signaling mechanisms by which they control energy expenditure remains unclear. Here,...
4.
Stypulkowski E, Feng Q, Joseph I, Farrell V, Flores J, Yu S, et al.
J Biol Chem
. 2021 Mar;
296:100488.
PMID: 33662399
Differentiation of mesenchymal stem cells into adipocyte requires coordination of external stimuli and depends upon the functionality of the primary cilium. The Rab8 small GTPases are regulators of intracellular transport...
5.
Kaneko K, Fu Y, Lin H, Cordonier E, Mo Q, Gao Y, et al.
J Clin Invest
. 2019 Aug;
129(9):3786-3791.
PMID: 31403469
Nutrient excess, a major driver of obesity, diminishes hypothalamic responses to exogenously administered leptin, a critical hormone of energy balance. Here, we aimed to identify a physiological signal that arises...
6.
Wei Q, Lee J, Wang H, Bongmba O, Wu C, Pradhan G, et al.
BMC Physiol
. 2017 Oct;
17(1):8.
PMID: 29058611
Background: Thermogenic impairment promotes obesity and insulin resistance. Adiponectin is an important regulator of energy homeostasis. While many beneficial metabolic effects of adiponectin resemble that of activated thermogenesis, the role...
7.
Mo Q, Salley J, Roshan T, Baer L, May F, Jaehnig E, et al.
JCI Insight
. 2017 Jun;
2(11).
PMID: 28570265
A fundamental challenge to our understanding of brown adipose tissue (BAT) is the lack of an animal model that faithfully represents human BAT. Such a model is essential for direct...
8.
Yu D, Gadkari M, Zhou Q, Yu S, Gao N, Guan Y, et al.
Genome Biol
. 2015 Oct;
16:211.
PMID: 26420038
Background: DNA methylation is an epigenetic mechanism central to development and maintenance of complex mammalian tissues, but our understanding of its role in intestinal development is limited. Results: We use...
9.
Nosavanh L, Yu D, Jaehnig E, Tong Q, Shen L, Chen M
Proc Natl Acad Sci U S A
. 2015 Apr;
112(16):5069-74.
PMID: 25848030
Although recent studies have shown that brown adipose tissue (BAT) arises from progenitor cells that also give rise to skeletal muscle, the developmental signals that control the formation of BAT...
10.
Nam D, Guo B, Chatterjee S, Chen M, Nelson D, Yechoor V, et al.
J Cell Sci
. 2015 Mar;
128(9):1835-47.
PMID: 25749863
The molecular clock is intimately linked to metabolic regulation, and brown adipose tissue plays a key role in energy homeostasis. However, whether the cell-intrinsic clock machinery participates in brown adipocyte...