Melanie Verreault
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Explore the profile of Melanie Verreault including associated specialties, affiliations and a list of published articles.
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26
Citations
316
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Recent Articles
11.
Bigo C, Kaeding J, El Husseini D, Rudkowska I, Verreault M, Vohl M, et al.
PPAR Res
. 2014 Aug;
2014:747014.
PMID: 25147562
Hypolipidemic fibrates activate the peroxisome proliferator-activated receptor (PPAR) α to modulate lipid oxidation and metabolism. The present study aimed at evaluating how 3 PPARα agonists, namely, fenofibrate, gemfibrozil, and Wy14,643,...
12.
Perreault M, Bialek A, Trottier J, Verreault M, Caron P, Milkiewicz P, et al.
PLoS One
. 2013 Nov;
8(11):e80994.
PMID: 24244729
Biliary obstruction, a severe cholestatic condition, results in a huge accumulation of toxic bile acids (BA) in the liver. Glucuronidation, a conjugation reaction, is thought to protect the liver by...
13.
Perreault M, Gauthier-Landry L, Trottier J, Verreault M, Caron P, Finel M, et al.
Drug Metab Dispos
. 2013 Jun;
41(9):1616-20.
PMID: 23756265
Bile acids (BA) are essential modulators of lipid, glucose, and cholesterol homeostasis, but they exert cytotoxic effects in the cholestatic liver. Glucuronidation, catalyzed by the UDP-glucuronosyltransferase (UGT) enzymes is a...
14.
Grosse L, Campeau A, Caron S, Morin F, Meunier K, Trottier J, et al.
Basic Clin Pharmacol Toxicol
. 2013 Mar;
113(2):92-102.
PMID: 23527766
Bicalutamide (Casodex(®) ) is a non-steroidal pure anti-androgen used in the treatment of localized prostate cancer. It is a racemate drug, and its activity resides in the (R)-enantiomer, with little...
15.
Paquet S, Fazli L, Grosse L, Verreault M, Tetu B, Rennie P, et al.
J Clin Endocrinol Metab
. 2011 Dec;
97(3):E428-32.
PMID: 22170718
Context: Androgens play major roles in prostate cancer initiation and development. In prostate cells, the human uridine diphosphate-glucuronosyltransferase (UGT)2B15 and UGT2B17 enzymes inactivate androgens. Objective: We investigated in vivo how...
16.
Rudkowska I, Caron-Dorval D, Verreault M, Couture P, Deshaies Y, Barbier O, et al.
Mol Nutr Food Res
. 2009 Nov;
54(4):543-50.
PMID: 19937854
Omega-3 fatty acids (FAs) may accelerate plasma triglyceride (TG) clearance by altering lipoprotein lipase (LPL) activity. Yet, the ability of n-3 FAs to increase LPL activity is dependent on transcription...
17.
The human UGT1A3 enzyme conjugates norursodeoxycholic acid into a C23-ester glucuronide in the liver
Trottier J, El Husseini D, Perreault M, Paquet S, Caron P, Bourassa S, et al.
J Biol Chem
. 2009 Nov;
285(2):1113-21.
PMID: 19889628
Norursodeoxycholic acid (norUDCA) exhibits efficient anti-cholestatic properties in an animal model of sclerosing cholangitis. norUDCA is eliminated as a C(23)-ester glucuronide (norUDCA-23G) in humans. The present study aimed at identifying...
18.
Verreault M, Kaeding J, Caron P, Trottier J, Grosse L, Houssin E, et al.
Drug Metab Rev
. 2009 Oct;
42(1):110-22.
PMID: 19831728
Recent progresses in molecular pharmacology approaches have allowed the identification and characterization of a series of nuclear receptors (NR) which efficiently control the level UDP-glucuronosyltransferase (UGT) genes expression. These regulatory...
19.
Rudkowska I, Verreault M, Barbier O, Vohl M
PPAR Res
. 2009 Mar;
2009:369602.
PMID: 19266045
Omega-3 fatty acids (FAs) have the potential to regulate gene expression via the peroxisome proliferator-activated receptor α (PPARα); therefore, genetic variations in this gene may impact its transcriptional activity on...
20.
Barbier O, Trottier J, Kaeding J, Caron P, Verreault M
Mol Cell Biochem
. 2009 Jan;
326(1-2):3-8.
PMID: 19130183
Bile acids subserve important physiological functions in the control of cholesterol homeostasis. Indeed, hepatic bile acid synthesis and biliary excretion constitute the main route for cholesterol removal from the human...