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Martin Perreault

Explore the profile of Martin Perreault including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 19
Citations 167
Followers 0
Related Specialties
Biochemistry
Chemistry
Pharmacology
Top 10 Co-Authors
Donald Poirier
Rene Maltais
Jenny Roy
Melanie Verreault
Jocelyn Trottier
Olivier Barbier
Patrick Caron
Raphael Dutour
Stephane Gobeil
Guy G Poirier
Published In
J Steroid Biochem Mol Biol
Int J Mol Sci
Clin Endocrinol (Oxf)
Drug Metab Dispos
Steroids
Affiliations
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Recent Articles
1.
Induction of Endoplasmic Reticulum Stress-Mediated Apoptosis by Aminosteroid RM-581 Efficiently Blocks the Growth of PC-3 Cancer Cells and Tumors Resistant or Not to Docetaxel
Maltais R, Roy J, Perreault M, Sato S, Levesque J, Poirier D
Int J Mol Sci . 2021 Oct; 22(20). PMID: 34681843
Aminosteroid derivative RM-581 was previously identified as an endoplasmic-reticulum (ER) stress inducer with potent in vitro and in vivo anticancer activities. We report its evaluation in androgen-independent prostate cancer (PC-3)...
2.
Omega-3 Polyunsaturated Fatty Acid: A Pharmaco-Nutraceutical Approach to Improve the Responsiveness to Ursodeoxycholic Acid
Therien A, Cieslak A, Verreault M, Perreault M, Trottier J, Gobeil S, et al.
Nutrients . 2021 Aug; 13(8). PMID: 34444777
Ursodeoxycholic acid (UDCA) is the first line therapy for the treatment of cholestatic and autoimmune liver diseases. Its clinical use is currently limited by a significant proportion of non-responder patients....
3.
Synthesis and biological evaluation of novel 1,4-benzodiazepin-3-one derivatives as potential antitumor agents against prostate cancer
Vezina-Dawod S, Perreault M, Guay L, Gerber N, Gobeil S, Biron E
Bioorg Med Chem . 2021 Aug; 45:116314. PMID: 34333393
A novel tumor suppressing agent was discovered against PC-3 prostate cancer cells from the screening of a 1,4-benzodiazepin-3-one library. In this study, 96 highly diversified 2,4,5-trisubstituted 1,4-benzodiazepin-3-one derivatives were prepared...
4.
16-Picolyl-androsterone derivative exhibits potent 17β-HSD3 inhibitory activity, improved metabolic stability and cytotoxic effect on various cancer cells: Synthesis, homology modeling and docking studies
Cortes-Benitez F, Roy J, Perreault M, Maltais R, Poirier D
J Steroid Biochem Mol Biol . 2021 Feb; 210:105846. PMID: 33609690
A new androsterone derivative bearing a 16β-picolyl group (compound 5; FCO-586-119) was synthetized in four steps from the lead compound 1 (RM-532-105). We measured its inhibitory activity on 17β-HSD3 using...
5.
Minor chemical modifications of the aminosteroid derivative RM-581 lead to major impact on its anticancer activity, metabolic stability and aqueous solubility
Maltais R, Perreault M, Roy J, Poirier D
Eur J Med Chem . 2020 Jan; 188:111990. PMID: 31893547
The aminosteroid (AM) RM-581 is built around a mestranol backbone and has recently emerged as this family's lead candidate, showing in vitro and in vivo potency over different types of...
6.
A- and D-Ring Structural Modifications of an Androsterone Derivative Inhibiting 17β-Hydroxysteroid Dehydrogenase Type 3: Chemical Synthesis and Structure-Activity Relationships
Cortes-Benitez F, Roy J, Perreault M, Maltais R, Poirier D
J Med Chem . 2019 Jul; 62(15):7070-7088. PMID: 31268309
Decreasing the intratumoral androgen biosynthesis by using an inhibitor of 17β-hydroxysteroid dehydrogenase type 3 (17β-HSD3) is a strategy to treat prostate cancer. The androsterone (ADT) derivative (RM-532-105) has shown strong...
7.
Induction of endoplasmic reticulum stress by aminosteroid derivative RM-581 leads to tumor regression in PANC-1 xenograft model
Perreault M, Maltais R, Roy J, Picard S, Popa I, Bertrand N, et al.
Invest New Drugs . 2018 Aug; 37(3):431-440. PMID: 30062573
The high fatality and morbidity of pancreatic cancer have remained almost unchanged over the last decades and new clinical therapeutic tools are urgently needed. We determined the cytotoxic activity of...
8.
Urinary Elimination of Bile Acid Glucuronides under Severe Cholestatic Situations: Contribution of Hepatic and Renal Glucuronidation Reactions
Perreault M, Wunsch E, Bialek A, Trottier J, Verreault M, Caron P, et al.
Can J Gastroenterol Hepatol . 2018 Jun; 2018:8096314. PMID: 29850459
Biliary obstruction, a severe cholestatic complication, causes accumulation of toxic bile acids (BAs) in liver cells. Glucuronidation, catalyzed by UDP-glucuronosyltransferase (UGT) enzymes, detoxifies cholestatic BAs. Using liquid chromatography coupled to...
9.
Parallel Solid-Phase Synthesis using a New Diethylsilylacetylenic Linker and Leading to Mestranol Derivatives with Potent Antiproliferative Activities on Multiple Cancer Cell Lines
Dutour R, Maltais R, Perreault M, Roy J, Poirier D
Anticancer Agents Med Chem . 2018 Mar; 18(10):1469-1481. PMID: 29521249
Background: RM-133 belongs to a new family of aminosteroid derivatives demonstrating interesting anticancer properties, as confirmed in vivo in four mouse cancer xenograft models. However, the metabolic stability of RM-133...
10.
Implication of STARD5 and cholesterol homeostasis disturbance in the endoplasmic reticulum stress-related response induced by pro-apoptotic aminosteroid RM-133
Perreault M, Maltais R, Kenmogne L, Letourneau D, LeHoux J, Gobeil S, et al.
Pharmacol Res . 2017 Dec; 128:52-60. PMID: 29287690
The aminosteroid derivative RM-133 is an effective anticancer molecule for which proof of concept has been achieved in several mouse xenograph models (HL-60, MCF-7, PANC-1 and OVCAR-3). To promote this...