McLane J Watson
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Explore the profile of McLane J Watson including associated specialties, affiliations and a list of published articles.
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12
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965
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Recent Articles
1.
Oswald B, DeCamp L, Longo J, Dahabieh M, Bunda N, Ma S, et al.
bioRxiv
. 2024 Nov;
PMID: 39605550
Reducing calorie intake without malnutrition limits tumor progression but the underlying mechanisms are poorly understood. Here we show that dietary restriction (DR) suppresses tumor growth by enhancing CD8 T cell-mediated...
2.
Kaymak I, Watson M, Oswald B, Ma S, Johnson B, DeCamp L, et al.
J Exp Med
. 2024 Aug;
221(9).
PMID: 39150482
Coordination of cellular metabolism is essential for optimal T cell responses. Here, we identify cytosolic acetyl-CoA production as an essential metabolic node for CD8 T cell function in vivo. We...
3.
DePeaux K, Rivadeneira D, Lontos K, Dean V, Gunn W, Watson M, et al.
J Exp Med
. 2023 Aug;
220(10).
PMID: 37552475
While checkpoint blockade immunotherapies have widespread success, they rely on a responsive immune infiltrate; as such, treatments enhancing immune infiltration and preventing immunosuppression are of critical need. We previously generated...
4.
Luda K, Longo J, Kitchen-Goosen S, Duimstra L, Ma E, Watson M, et al.
Immunity
. 2023 Jul;
56(9):2021-2035.e8.
PMID: 37516105
Environmental nutrient availability influences T cell metabolism, impacting T cell function and shaping immune outcomes. Here, we identified ketone bodies (KBs)-including β-hydroxybutyrate (βOHB) and acetoacetate (AcAc)-as essential fuels supporting CD8...
5.
Lontos K, Wang Y, Joshi S, Frisch A, Watson M, Kumar A, et al.
J Immunother Cancer
. 2023 Mar;
11(3).
PMID: 36914208
Background: Cellular immunotherapies for cancer represent a means by which a patient's immune system can be augmented with high numbers of tumor-specific T cells. Chimeric antigen receptor (CAR) therapy involves...
6.
Vignali P, DePeaux K, Watson M, Ye C, Ford B, Lontos K, et al.
Nat Immunol
. 2022 Dec;
24(2):267-279.
PMID: 36543958
CD8 T cells are critical for elimination of cancer cells. Factors within the tumor microenvironment (TME) can drive these cells to a hypofunctional state known as exhaustion. The most terminally...
7.
Longo J, Watson M, Vos M, Williams K, Jones R
Mol Cell
. 2022 Aug;
82(16):2918-2921.
PMID: 35985300
Zhang et al. (2022) show that TCR signaling promotes the phosphorylation and activation of glycogen phosphorylase B (PYGB) in CD8 memory T (Tmem) cells. PYGB-dependent glycogen mobilization provides a carbon...
8.
Kaymak I, Luda K, Duimstra L, Ma E, Longo J, Dahabieh M, et al.
Cell Metab
. 2022 Aug;
34(9):1298-1311.e6.
PMID: 35981545
How environmental nutrient availability impacts T cell metabolism and function remains poorly understood. Here, we report that the presence of physiologic carbon sources (PCSs) in cell culture medium broadly impacts...
9.
Watson M, Delgoffe G
J Clin Invest
. 2022 Jan;
132(2).
PMID: 35040434
As cancers progress, they produce a local environment that acts to redirect, paralyze, exhaust, or otherwise evade immune detection and destruction. The tumor microenvironment (TME) has long been characterized as...
10.
Watson M, Vignali P, Mullett S, Overacre-Delgoffe A, Peralta R, Grebinoski S, et al.
Nature
. 2021 Feb;
591(7851):645-651.
PMID: 33589820
Regulatory T (T) cells, although vital for immune homeostasis, also represent a major barrier to anti-cancer immunity, as the tumour microenvironment (TME) promotes the recruitment, differentiation and activity of these...