Mattia Deluigi
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Explore the profile of Mattia Deluigi including associated specialties, affiliations and a list of published articles.
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7
Citations
75
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Recent Articles
1.
Abdul-Ridha A, de Zhang L, Betrie A, Deluigi M, Vaid T, Whitehead A, et al.
ACS Chem Neurosci
. 2024 Jan;
15(3):671-684.
PMID: 38238043
α-, α-, and α-adrenoceptors (α-ARs) are members of the adrenoceptor G protein-coupled receptor family that are activated by adrenaline (epinephrine) and noradrenaline. α-ARs are clinically targeted using antagonists that have...
2.
Baumann C, Chiang W, Valsecchi R, Jurt S, Deluigi M, Schuster M, et al.
Protein Sci
. 2023 Oct;
32(11):e4801.
PMID: 37805830
G protein-coupled receptors (GPCRs) are medically important membrane proteins that sample inactive, intermediate, and active conformational states characterized by relatively slow interconversions (~μs-ms). On a faster timescale (~ps-ns), the conformational...
3.
Deluigi M, Morstein L, Schuster M, Klenk C, Merklinger L, Cridge R, et al.
Nat Commun
. 2022 Jan;
13(1):382.
PMID: 35046410
α-adrenergic receptors (αARs) are G protein-coupled receptors that regulate vital functions of the cardiovascular and nervous systems. The therapeutic potential of αARs, however, is largely unexploited and hampered by the...
4.
Deluigi M, Klipp A, Klenk C, Merklinger L, Eberle S, Morstein L, et al.
Sci Adv
. 2021 Feb;
7(5).
PMID: 33571132
Neurotensin receptor 1 (NTSR1) and related G protein-coupled receptors of the ghrelin family are clinically unexploited, and several mechanistic aspects of their activation and inactivation have remained unclear. Enabled by...
5.
Schuster M, Deluigi M, Pantic M, Vacca S, Baumann C, Scott D, et al.
Biochim Biophys Acta Biomembr
. 2020 May;
1862(10):183354.
PMID: 32413443
Sample preparation for NMR studies of G protein-coupled receptors faces special requirements: Proteins need to be stable for prolonged measurements at elevated temperatures, they should ideally be uniformly labeled with...
6.
Yong K, Vaid T, Shilling P, Wu F, Williams L, Deluigi M, et al.
ACS Chem Biol
. 2018 Mar;
13(4):1090-1102.
PMID: 29537256
α- and α-adrenoceptors (α-AR and α-AR) are closely related G protein-coupled receptors (GPCRs) that modulate the cardiovascular and nervous systems in response to binding epinephrine and norepinephrine. The GPCR gene...
7.
Egloff P, Deluigi M, Heine P, Balada S, Pluckthun A
Protein Expr Purif
. 2014 Dec;
108:106-114.
PMID: 25461958
G protein-coupled receptors (GPCRs) are key players of cell signaling, thus representing important drug targets for the treatment of human diseases. Since inherent difficulties in receptor production and handling have...