Ross A D Bathgate
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Explore the profile of Ross A D Bathgate including associated specialties, affiliations and a list of published articles.
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203
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3126
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Recent Articles
1.
Feng Y, Escudero Castelan N, Hossain M, Wu H, Katayama H, Smith S, et al.
BMC Biol
. 2025 Feb;
23(1):59.
PMID: 40001176
Background: Relaxins are a family of peptides that regulate reproductive physiology in vertebrates. Evidence that this is an evolutionarily ancient role of relaxins has been provided by the discovery of...
2.
Wu H, Hartono H, Handley T, Hoare B, Rosengren K, Chalmers D, et al.
J Med Chem
. 2024 Nov;
67(23):20966-20979.
PMID: 39568362
Insulin-like peptide 5 (INSL5) targets the G protein-coupled receptor, relaxin family peptide receptor 4 (RXFP4), predominantly coexpressed in the colorectum. While INSL5 also binds to the related receptor RXFP3, it...
3.
Syryn H, Van de Velde J, De Clercq G, Verdin H, Dheedene A, Peelman F, et al.
Hum Reprod
. 2024 Sep;
39(10):2353-2363.
PMID: 39222519
Study Question: Does RXFP2 disruption impair male fertility? Summary Answer: We identified biallelic variants in RXFP2 in patients with male infertility due to spermatogenic arrest at the spermatid stage, supporting...
4.
Agoulnik I, Kaftanovskaya E, Myhr C, Bathgate R, Kocan M, Peng Y, et al.
Biochem Pharmacol
. 2024 Jun;
227:116401.
PMID: 38945278
The peptide hormone relaxin plays a critical role in tissue remodeling in a variety of tissues through activation of its cognate receptor, RXFP1. Relaxin's ability to modify extracellular matrices has...
5.
Berger O, Choi W, Ko C, Thompson M, Avram M, Scott D, et al.
ACS Pharmacol Transl Sci
. 2024 May;
7(5):1252-1261.
PMID: 38751631
Hepatorenal syndrome (HRS) is a life-threatening complication of end-stage liver disease first reported over a century ago, but its management still poses an unmet challenge. A therapeutic agent found to...
6.
Navarro-Sanchez M, Gil-Miravet I, Montero-Caballero D, Bathgate R, Hossain M, Castillo-Gomez E, et al.
Biochem Pharmacol
. 2024 May;
225:116264.
PMID: 38710334
The retrosplenial cortex (RSC) plays a central role in processing contextual fear conditioning. In addition to corticocortical and thalamocortical projections, the RSC receives subcortical inputs, including a substantial projection from...
7.
Wu H, Handley T, Hoare B, Hartono H, Scott D, Chalmers D, et al.
Biochem Pharmacol
. 2024 Apr;
224:116239.
PMID: 38679208
Human insulin-like peptide 5 (INSL5) is a gut hormone produced by colonic L-cells, and its biological functions are mediated by Relaxin Family Peptide Receptor 4 (RXFP4). Our preliminary data indicated...
8.
Wu H, Hoare B, Handley T, Hossain M, Bathgate R
Biochem Pharmacol
. 2024 Apr;
224:116238.
PMID: 38677442
INSL5 and relaxin-3 are relaxin family peptides with important roles in gut and brain function, respectively. They mediate their actions through the class A GPCRs RXFP4 and RXFP3. RXFP4 has...
9.
Wu H, Praveen P, Handley T, Chandrashekar C, Cummins S, Bathgate R, et al.
Chemistry
. 2024 Apr;
30(33):e202400933.
PMID: 38609334
A relaxin-like gonad-stimulating peptide (RGP), Aso-RGP, featuring six cysteine residues, was identified in the Crown-of-Thorns Starfish (COTS, Acanthaster cf. solaris) and initially produced through recombinant yeast expression. This method yielded...
10.
Abdul-Ridha A, de Zhang L, Betrie A, Deluigi M, Vaid T, Whitehead A, et al.
ACS Chem Neurosci
. 2024 Jan;
15(3):671-684.
PMID: 38238043
α-, α-, and α-adrenoceptors (α-ARs) are members of the adrenoceptor G protein-coupled receptor family that are activated by adrenaline (epinephrine) and noradrenaline. α-ARs are clinically targeted using antagonists that have...