Oliver Zerbe
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Explore the profile of Oliver Zerbe including associated specialties, affiliations and a list of published articles.
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99
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1287
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Recent Articles
1.
Liu P, Baumann C, Streuli D, Zerbe O
Protein Sci
. 2024 Oct;
33(11):e5186.
PMID: 39446023
Metallothioneins (MTs) are small proteins that coordinate d-block metal ions in sulfur-metal clusters to control metal ion concentrations within the cell. Here we study metal cluster formation in the MT...
2.
Williams E, Schiefelbein K, Schuster M, Ahmed I, De Vries M, Beveridge R, et al.
Chem Sci
. 2024 Jun;
15(23):8756-8765.
PMID: 38873065
Protein-protein interactions of c-Myc (MYC) are often regulated by post-translational modifications (PTMs), such as phosphorylation, and crosstalk thereof. Studying these interactions requires proteins with unique PTM patterns, which are challenging...
3.
Schiefelbein K, Lang J, Schuster M, Grigglestone C, Striga R, Bigler L, et al.
J Am Chem Soc
. 2024 May;
146(25):17261-17269.
PMID: 38759637
Many peptidic natural products, such as lasso peptides, cyclic peptides, and cyclotides, are conformationally constrained and show biological stability, making them attractive scaffolds for drug development. Although many peptides can...
4.
Cucuzza S, Sitnik M, Jurt S, Michel E, Dai W, Muntener T, et al.
Nat Commun
. 2023 Nov;
14(1):7823.
PMID: 38016954
Ultra-tight binding is usually observed for proteins associating with rigidified molecules. Previously, we demonstrated that femtomolar binders derived from the Armadillo repeat proteins (ArmRPs) can be designed to interact very...
5.
Baumann C, Chiang W, Valsecchi R, Jurt S, Deluigi M, Schuster M, et al.
Protein Sci
. 2023 Oct;
32(11):e4801.
PMID: 37805830
G protein-coupled receptors (GPCRs) are medically important membrane proteins that sample inactive, intermediate, and active conformational states characterized by relatively slow interconversions (~μs-ms). On a faster timescale (~ps-ns), the conformational...
6.
Valsecchi R, Baumann C, Lila A, Zerbe O
Metallomics
. 2023 Sep;
15(10).
PMID: 37738453
Metallothioneins (MTs) are small proteins present in all kingdoms of life. Their high cysteine content enables them to bind metal ions, such as Zn2+, Cd2+, and Cu+, providing means for...
7.
Baumann C, Zerbe O
Proteins
. 2023 Jul;
92(1):15-23.
PMID: 37497770
Leucine and Isoleucine are two amino acids that differ only by the positioning of one methyl group. This small difference can have important consequences in α-helices, as the β-branching of...
8.
Oi K, Moehle K, Schuster M, Zerbe O
Molecules
. 2023 Jun;
28(11).
PMID: 37298811
The cationic antimicrobial ß-hairpin, thanatin, was recently developed into drug-like analogues active against carbapenem-resistant Enterobacteriaceae (CRE). The analogues represent new antibiotics with a novel mode of action targeting LptA in...
9.
Schuster M, Brabet E, Oi K, Desjonqueres N, Moehle K, Le Poupon K, et al.
Sci Adv
. 2023 May;
9(21):eadg3683.
PMID: 37224246
The rise of antimicrobial resistance poses a substantial threat to our health system, and, hence, development of drugs against novel targets is urgently needed. The natural peptide thanatin kills Gram-negative...
10.
Santhana Kumar K, Brunner C, Schuster M, Kopp L, Gries A, Yan S, et al.
Cell Oncol (Dordr)
. 2022 Dec;
46(2):331-356.
PMID: 36495366
Purpose: Aberrant activation of the fibroblast growth factor receptor (FGFR) family of receptor tyrosine kinases drives oncogenic signaling through its proximal adaptor protein FRS2. Precise disruption of this disease-causing signal...