Matthias Lehr
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Explore the profile of Matthias Lehr including associated specialties, affiliations and a list of published articles.
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60
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246
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Recent Articles
1.
Borecki D, Vilsendorf I, Fabian J, Lehr M
Med Chem
. 2024 Jul;
20(10):969-985.
PMID: 39041279
Background: Cytosolic phospholipase A2α (cPLA) is the key enzyme that initiates the arachidonic acid cascade through which pro-inflammatory lipid mediators can be formed. Therefore, cPLA is considered an interesting target...
2.
Vilsendorf I, Einerhand J, Mulac D, Langer K, Lehr M
RSC Med Chem
. 2024 Feb;
15(2):641-659.
PMID: 38389890
Cytosolic phospholipase Aα (cPLAα) is considered an interesting target for the development of new anti-inflammatory drugs, as it is significantly involved in the formation of pro-inflammatory lipid mediators. Recently, in...
3.
Postges T, Galster F, Kampschulze J, Hanekamp W, Lehr M
Bioorg Med Chem
. 2023 Dec;
98:117558.
PMID: 38142562
Vascular adhesion protein-1 (VAP-1), also known as plasma amine oxidase or semicarbazide-sensitive amine oxidase, is an enzyme that degrades primary amines to aldehydes with the formation of hydrogen peroxide and...
4.
Ekodo Voundi M, Hanekamp W, Lehr M
RSC Med Chem
. 2023 Oct;
14(10):2079-2088.
PMID: 37859716
The serine hydrolases cytosolic phospholipase Aα (cPLAα) and fatty acid amide hydrolase (FAAH) are interesting targets for the development of new anti-inflammatory and analgesic drugs. Structural modifications of a potent...
5.
Subeska A, Ekodo Voundi M, Hanekamp W, Mulac D, Langer K, Lehr M
Bioorg Med Chem Lett
. 2023 Jun;
92:129374.
PMID: 37315699
Cytosolic phospholipase Aα (cPLAα), the key enzyme of the arachidonic acid cascade, is considered to be an interesting target for the development of new anti-inflammatory drugs. Potent inhibitors of the...
6.
Lange T, Depmeier T, Strunker T, Lehr M
J Pharm Biomed Anal
. 2023 Apr;
229:115354.
PMID: 37003086
N-Acyl phosphatidylethanolamine-hydrolyzing phospholipase D (NAPE-PLD) is the major enzyme for the biosynthesis of the endocannabinoid anandamide. The role of NAPE-PLD in various physiological and pathophysiological conditions is currently under investigation....
7.
Postges T, Lehr M
Pharmacol Res Perspect
. 2023 Jan;
11(1):e01051.
PMID: 36655303
Scientific literature describes that sumatriptan is metabolized by oxidative deamination of its dimethylaminoethyl residue by monoamine oxidase A (MAO A) and not by cytochrome P450 (CYP)-mediated demethylation, as is usual...
8.
Subeska A, Althaus J, Hake T, Hanekamp W, Bettenworth D, Mulac D, et al.
Bioorg Med Chem
. 2022 Dec;
77:117110.
PMID: 36495814
Indole-5-carboxylic acids with 3-aryloxy-2‑oxopropyl residues in position 1 have been shown to be potent inhibitors of cytosolic phospholipase Aα (cPLAα), an enzyme involved in the formation of pro-inflammatory lipid mediators....
9.
Depmeier T, Lange T, Hanekamp W, Strunker T, Lehr M
Anal Biochem
. 2022 Sep;
657:114889.
PMID: 36113549
1,2-Diacylglycerol lipases (DAGLs) are the most important enzymes for the biosynthesis of the endocannabinoid 2-arachidonoylglycerol (2-AG), and their role in various pathophysiological conditions is currently under investigation. We synthesized a...
10.
Galster F, Postges T, Hanekamp W, Lehr M
Arch Pharm (Weinheim)
. 2022 May;
355(8):e2200111.
PMID: 35507758
Amine oxidase copper containing 3 (AOC3), also known as plasma amine oxidase, semicarbazide-sensitive amine oxidase, or vascular adhesion protein-1, catalyzes the oxidative deamination of primary amines to aldehydes using copper...