Matthias Lehr
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Explore the profile of Matthias Lehr including associated specialties, affiliations and a list of published articles.
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60
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246
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Recent Articles
11.
Krybus M, Sieradzki M, Fahimi E, Metry S, Nusing R, Geisslinger G, et al.
Biomed Pharmacother
. 2022 Mar;
148:112786.
PMID: 35259564
Background: Non-allergic angioedema is a potentially life-threatening condition caused by accumulation of bradykinin and subsequent activation of bradykinin type 2 receptors (B2). Since COX activity plays a pivotal role in...
12.
Barth M, Rudolph S, Kampschulze J, Vilsendorf I, Hanekamp W, Mulac D, et al.
ChemMedChem
. 2022 Jan;
17(9):e202100757.
PMID: 35072346
A series of hexafluoroisopropyl carbamates with indolylalkyl- and azaindolylalkyl-substituents at the carbamate nitrogen was synthesized and evaluated for inhibition of the endocannabinoid degrading enzymes fatty acid amide hydrolase (FAAH) and...
13.
Rudolph S, Dahlhaus H, Hanekamp W, Albers C, Barth M, Michels G, et al.
ACS Omega
. 2021 May;
6(20):13466-13483.
PMID: 34056494
A series of aryl -[ω-(6-fluoroindol-1-yl)alkyl]carbamates with alkyl spacers of varying lengths between the indole and the carbamate group and with differently substituted aryl moieties at the carbamate oxygen were synthesized...
14.
Fabian J, Mergemeier K, Lehr M
Prostaglandins Other Lipid Mediat
. 2021 May;
155:106551.
PMID: 33940184
An automatic on-line dilution/on-line solid phase extraction (SPE) system has been developed for the detection of metabolites of the arachidonic acid cascade in platelets. The method allows the direct injection...
15.
Korff M, Imberg L, Will J, Buckreiss N, Kalinina S, Wenzel B, et al.
J Med Chem
. 2020 Oct;
63(21):13159-13186.
PMID: 33089691
We herein report the conventional and microscale parallel synthesis of selective inhibitors of human blood coagulation factor XIIa and thrombin exhibiting a 1,2,4-triazol-5-amine scaffold. Structural variations of this scaffold allowed...
16.
Mergemeier K, Galster F, Lehr M
J Enzyme Inhib Med Chem
. 2018 Nov;
34(1):144-149.
PMID: 30427224
Recently, we have described a method for evaluation of plasma amine oxidase (PAO) inhibitors, which monitors the formation of 6-(5-phenyl-2H-tetrazol-2-yl)hexanal from the corresponding amine substrate by HPLC with UV-detection using...
17.
Garzinsky D, Zahov S, Ekodo Voundi M, Hanekamp W, Lehr M
Eur J Med Chem
. 2018 Oct;
160:183-192.
PMID: 30340141
A series of derivatives of 1-(4-octylphenoxy)-3-(2H-tetrazol-2-yl)propan-2-one (3) and 1-(4-octylphenoxy)-3-(1H-tetrazol-1-yl)propan-2-one (4) was synthesized and tested for fatty acid amide hydrolase (FAAH) inhibitory potency and phase I metabolic stability. Introduction of certain...
18.
Dahlhaus H, Hanekamp W, Lehr M
Medchemcomm
. 2018 Aug;
8(3):616-620.
PMID: 30108777
A series of phenyl 4-[(indol-1-yl)alkyl]piperidine carbamates was synthesized and tested for inhibition of the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) and for metabolic stability in rat liver S9...
19.
Mergemeier K, Lehr M
Anal Biochem
. 2018 Mar;
549:29-38.
PMID: 29550344
Recently, we have described an HPLC-UV assay for the evaluation of inhibitors of plasma amine oxidase (PAO) using 6-(5-phenyl-2H-tetrazol-2-yl)hexan-1-amine (4) as a new type of substrate. Now we studied, whether...
20.
Ludwig P, Huber M, Lehr M, Wegener M, Zerulla K, Lange C, et al.
Microbiology (Reading)
. 2018 Feb;
164(4):646-658.
PMID: 29469690
Translation initiation in 50-70 % of transcripts in Escherichia coli requires base pairing between the Shine-Dalgarno (SD) motif in the mRNA and the anti-SD motif at the 3' end of...