Matthew S Wilken
Overview
Explore the profile of Matthew S Wilken including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
2505
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Recent Articles
1.
VandenBosch L, Wohl S, Wilken M, Hooper M, Finkbeiner C, Cox K, et al.
Sci Rep
. 2020 Aug;
10(1):13615.
PMID: 32788677
Diseases and damage to the retina lead to losses in retinal neurons and eventual visual impairment. Although the mammalian retina has no inherent regenerative capabilities, fish have robust regeneration from...
2.
Chen Z, Kibler R, Hunt A, Busch F, Pearl J, Jia M, et al.
Science
. 2020 Apr;
368(6486):78-84.
PMID: 32241946
The design of modular protein logic for regulating protein function at the posttranscriptional level is a challenge for synthetic biology. Here, we describe the design of two-input AND, OR, NAND,...
3.
Jorstad N, Wilken M, Todd L, Finkbeiner C, Nakamura P, Radulovich N, et al.
Cell Rep
. 2020 Feb;
30(7):2195-2208.e5.
PMID: 32075759
Müller glia (MG) serve as sources for retinal regeneration in non-mammalian vertebrates. We find that this process can be induced in mouse MG, after injury, by transgenic expression of the...
4.
Wilkerson B, Chitsazan A, VandenBosch L, Wilken M, Reh T, Bermingham-McDonogh O
Sci Rep
. 2019 Jun;
9(1):9060.
PMID: 31227770
Hearing loss is often due to the absence or the degeneration of hair cells in the cochlea. Understanding the mechanisms regulating the generation of hair cells may therefore lead to...
5.
Hoshino A, Ratnapriya R, Brooks M, Chaitankar V, Wilken M, Zhang C, et al.
Dev Cell
. 2017 Dec;
43(6):763-779.e4.
PMID: 29233477
Clinical and genetic heterogeneity associated with retinal diseases makes stem-cell-based therapies an attractive strategy for personalized medicine. However, we have limited understanding of the timing of key events in the...
6.
Jorstad N, Wilken M, Grimes W, Wohl S, VandenBosch L, Yoshimatsu T, et al.
Nature
. 2017 Jul;
548(7665):103-107.
PMID: 28746305
Many retinal diseases lead to the loss of retinal neurons and cause visual impairment. The adult mammalian retina has little capacity for regeneration. By contrast, teleost fish functionally regenerate their...
7.
Wilken M, Reh T
Curr Opin Genet Dev
. 2016 Jul;
40:57-64.
PMID: 27379897
Retinal regeneration from resident Müller glia cells is robust in teleost fish, but is severely limited in birds and mammals. After neurotoxic injury, chick Müller glia can proliferate, and activate...
8.
Ueki Y, Wilken M, Cox K, Chipman L, Jorstad N, Sternhagen K, et al.
Proc Natl Acad Sci U S A
. 2015 Oct;
112(44):13717-22.
PMID: 26483457
Müller glial cells are the source of retinal regeneration in fish and birds; although this process is efficient in fish, it is less so in birds and very limited in...
9.
Zhang J, Taylor R, La Torre A, Wilken M, Cox K, Reh T, et al.
Dev Biol
. 2015 May;
403(2):128-38.
PMID: 25989023
Epigenetic regulation, including histone modification, is a critical component of gene regulation, although precisely how this contributes to the development of complex tissues such as the neural retina is still...
10.
Wilken M, Brzezinski J, La Torre A, Siebenthall K, Thurman R, Sabo P, et al.
Epigenetics Chromatin
. 2015 May;
8:8.
PMID: 25972927
Background: The brain, spinal cord, and neural retina comprise the central nervous system (CNS) of vertebrates. Understanding the regulatory mechanisms that underlie the enormous cell-type diversity of the CNS is...