Thomas A Reh
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Explore the profile of Thomas A Reh including associated specialties, affiliations and a list of published articles.
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120
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7045
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Recent Articles
1.
Pavlou M, Probst M, Kaplan L, Filippova E, Prieve A, Rieke F, et al.
EMBO Mol Med
. 2025 Mar;
PMID: 40050705
The lack of regeneration in the human central nervous system (CNS) has major health implications. To address this, we previously used transgenic mouse models to show that neurogenesis can be...
2.
Vollger M, Korlach J, Eldred K, Swanson E, Underwood J, Bohaczuk S, et al.
Nat Genet
. 2025 Jan;
57(2):469-479.
PMID: 39880924
Resolving the molecular basis of a Mendelian condition remains challenging owing to the diverse mechanisms by which genetic variants cause disease. To address this, we developed a synchronized long-read genome,...
3.
Wohlschlegel J, Kierney F, Arakelian K, Luxardi G, Suvarnpradip N, Hoffer D, et al.
Proc Natl Acad Sci U S A
. 2025 Jan;
122(3):e2417228122.
PMID: 39823300
Retinal diseases often lead to degeneration of specific retinal cell types with currently limited therapeutic options to replace the lost neurons. Previous studies have reported that overexpression of or combinations...
4.
Tresenrider A, Hooper M, Todd L, Kierney F, Blasdel N, Trapnell C, et al.
Elife
. 2024 Dec;
12.
PMID: 39665620
Retinal degeneration in mammals causes permanent loss of vision, due to an inability to regenerate naturally. Some non-mammalian vertebrates show robust regeneration, via Muller glia (MG). We have recently made...
5.
Blasdel N, Bhattacharya S, Donaldson P, Reh T, Todd L
J Neurosci
. 2024 Oct;
44(46).
PMID: 39353729
Endogenous reprogramming of glia into neurogenic progenitors holds great promise for neuron restoration therapies. Using lessons from regenerative species, we have developed strategies to stimulate mammalian Müller glia to regenerate...
6.
Zuo Z, Cheng X, Ferdous S, Shao J, Li J, Bao Y, et al.
Nat Commun
. 2024 Aug;
15(1):6792.
PMID: 39117640
The development of the retina is under tight temporal and spatial control. To gain insights into the molecular basis of this process, we generate a single-nuclei dual-omic atlas of the...
7.
Pavlou M, Probst M, Blasdel N, Prieve A, Reh T
Stem Cell Reports
. 2024 Jan;
19(2):239-253.
PMID: 38278154
Regeneration of neurons has important implications for human health, and the retina provides an accessible system to study the potential of replacing neurons following injury. In previous work, we generated...
8.
Wohlschlegel J, Finkbeiner C, Hoffer D, Kierney F, Prieve A, Murry A, et al.
Stem Cell Reports
. 2023 Dec;
18(12):2400-2417.
PMID: 38039971
In mammals, loss of retinal cells due to disease or trauma is an irreversible process that can lead to blindness. Interestingly, regeneration of retinal neurons is a well established process...
9.
Johnson T, Baranov P, Di Polo A, Fortune B, Gokoffski K, Goldberg J, et al.
Ophthalmol Sci
. 2023 Nov;
3(4):100390.
PMID: 38025164
Purpose: The Retinal Ganglion Cell (RGC) Repopulation, Stem Cell Transplantation, and Optic Nerve Regeneration (RReSTORe) consortium was founded in 2021 to help address the numerous scientific and clinical obstacles that...
10.
Soucy J, Todd L, Kriukov E, Phay M, Malechka V, Rivera J, et al.
Proc Natl Acad Sci U S A
. 2023 Nov;
120(46):e2302089120.
PMID: 37931105
Ongoing cell therapy trials have demonstrated the need for precision control of donor cell behavior within the recipient tissue. We present a methodology to guide stem cell-derived and endogenously regenerated...