Jeff Vierstra
Overview
Explore the profile of Jeff Vierstra including associated specialties, affiliations and a list of published articles.
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23
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5201
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Recent Articles
1.
Buyan A, Meshcheryakov G, Safronov V, Abramov S, Boytsov A, Nozdrin V, et al.
Nat Commun
. 2025 Feb;
16(1):1739.
PMID: 39966391
High-throughput sequencing facilitates large-scale studies of gene regulation and allows tracing the associations of individual genomic variants with changes in gene regulation and expression. Compared to classic association studies, the...
2.
Gobbo F, Zingariello M, Verachi P, Falchi M, Arciprete F, Martelli F, et al.
bioRxiv
. 2023 Jul;
PMID: 37425686
Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disorder with limited therapeutic options. Insufficient understanding of driver mutations and poor fidelity of currently available animal models has limited the...
3.
Georgolopoulos G, Psatha N, Iwata M, Nishida A, Som T, Yiangou M, et al.
Nat Commun
. 2021 Nov;
12(1):6790.
PMID: 34815405
Lineage commitment and differentiation is driven by the concerted action of master transcriptional regulators at their target chromatin sites. Multiple efforts have characterized the key transcription factors (TFs) that determine...
4.
Vierstra J, Lazar J, Sandstrom R, Halow J, Lee K, Bates D, et al.
Nature
. 2020 Jul;
583(7818):729-736.
PMID: 32728250
Combinatorial binding of transcription factors to regulatory DNA underpins gene regulation in all organisms. Genetic variation in regulatory regions has been connected with diseases and diverse phenotypic traits, but it...
5.
Meuleman W, Muratov A, Rynes E, Halow J, Lee K, Bates D, et al.
Nature
. 2020 Jul;
584(7820):244-251.
PMID: 32728217
DNase I hypersensitive sites (DHSs) are generic markers of regulatory DNA and contain genetic variations associated with diseases and phenotypic traits. We created high-resolution maps of DHSs from 733 human...
6.
Georgolopoulos G, Iwata M, Psatha N, Yiangou M, Vierstra J
J Biol Res (Thessalon)
. 2019 Jul;
26:4.
PMID: 31360678
Background: Hematopoiesis is a model-system for studying cellular development and differentiation. Phenotypic and functional characterization of hematopoietic progenitors has significantly aided our understanding of the mechanisms that govern fate choice,...
7.
Breeze C, Reynolds A, Dongen J, Dunham I, Lazar J, Neph S, et al.
Bioinformatics
. 2019 Jun;
35(22):4767-4769.
PMID: 31161210
Summary: The Illumina Infinium EPIC BeadChip is a new high-throughput array for DNA methylation analysis, extending the earlier 450k array by over 400 000 new sites. Previously, a method named...
8.
Vierstra J, Stamatoyannopoulos J
Nat Methods
. 2016 Feb;
13(3):213-21.
PMID: 26914205
The advent of DNA footprinting with DNase I more than 35 years ago enabled the systematic analysis of protein-DNA interactions, and the technique has been instrumental in the decoding of...
9.
Maurano M, Haugen E, Sandstrom R, Vierstra J, Shafer A, Kaul R, et al.
Nat Genet
. 2015 Dec;
48(1):101.
PMID: 26711113
No abstract available.
10.
He X, Tillo D, Vierstra J, Syed K, Deng C, Ray G, et al.
Genome Biol Evol
. 2015 Oct;
7(11):3155-69.
PMID: 26507798
In mammals, the cytosine in CG dinucleotides is typically methylated producing 5-methylcytosine (5mC), a chemically less stable form of cytosine that can spontaneously deaminate to thymidine resulting in a T•G...