Robert E Thurman
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Explore the profile of Robert E Thurman including associated specialties, affiliations and a list of published articles.
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33
Citations
16716
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Recent Articles
1.
Smith A, Thurman R, Zeng W, Grogan B, Lucas S, Gutierrez G, et al.
Front Immunol
. 2023 Nov;
14:1280986.
PMID: 38022590
TIGIT is an immune checkpoint receptor expressed on activated and memory T cells, immunosuppressive T regulatory cells, and natural killer (NK) cells. TIGIT has emerged as an attractive target for...
2.
Sullivan A, Arsovski A, Thompson A, Sandstrom R, Thurman R, Neph S, et al.
Front Plant Sci
. 2019 Dec;
10:1434.
PMID: 31798605
The genome is reprogrammed during development to produce diverse cell types, largely through altered expression and activity of key transcription factors. The accessibility and critical functions of epidermal cells have...
3.
Kundaje A, Meuleman W, Ernst J, Bilenky M, Yen A, Heravi-Moussavi A, et al.
Nature
. 2015 Feb;
518(7539):317-30.
PMID: 25693563
The reference human genome sequence set the stage for studies of genetic variation and its association with human disease, but epigenomic studies lack a similar reference. To address this need,...
4.
Vierstra J, Rynes E, Sandstrom R, Zhang M, Canfield T, Hansen R, et al.
Science
. 2014 Nov;
346(6212):1007-12.
PMID: 25411453
To study the evolutionary dynamics of regulatory DNA, we mapped >1.3 million deoxyribonuclease I-hypersensitive sites (DHSs) in 45 mouse cell and tissue types, and systematically compared these with human DHS...
5.
Pope B, Ryba T, Dileep V, Yue F, Wu W, Denas O, et al.
Nature
. 2014 Nov;
515(7527):402-5.
PMID: 25409831
Eukaryotic chromosomes replicate in a temporal order known as the replication-timing program. In mammals, replication timing is cell-type-specific with at least half the genome switching replication timing during development, primarily...
6.
Stergachis A, Neph S, Sandstrom R, Haugen E, Reynolds A, Zhang M, et al.
Nature
. 2014 Nov;
515(7527):365-70.
PMID: 25409825
The basic body plan and major physiological axes have been highly conserved during mammalian evolution, yet only a small fraction of the human genome sequence appears to be subject to...
7.
Yue F, Cheng Y, Breschi A, Vierstra J, Wu W, Ryba T, et al.
Nature
. 2014 Nov;
515(7527):355-64.
PMID: 25409824
The laboratory mouse shares the majority of its protein-coding genes with humans, making it the premier model organism in biomedical research, yet the two mammals differ in significant ways. To...
8.
Sullivan A, Arsovski A, Lempe J, Bubb K, Weirauch M, Sabo P, et al.
Cell Rep
. 2014 Sep;
8(6):2015-2030.
PMID: 25220462
Our understanding of gene regulation in plants is constrained by our limited knowledge of plant cis-regulatory DNA and its dynamics. We mapped DNase I hypersensitive sites (DHSs) in A. thaliana...
9.
Polak P, Lawrence M, Haugen E, Stoletzki N, Stojanov P, Thurman R, et al.
Nat Biotechnol
. 2013 Dec;
32(1):71-5.
PMID: 24336318
Carcinogenesis and neoplastic progression are mediated by the accumulation of somatic mutations. Here we report that the local density of somatic mutations in cancer genomes is highly reduced specifically in...
10.
Stergachis A, Neph S, Reynolds A, Humbert R, Miller B, Paige S, et al.
Cell
. 2013 Aug;
154(4):888-903.
PMID: 23953118
Cellular-state information between generations of developing cells may be propagated via regulatory regions. We report consistent patterns of gain and loss of DNase I-hypersensitive sites (DHSs) as cells progress from...