Mario C Chang
Overview
Explore the profile of Mario C Chang including associated specialties, affiliations and a list of published articles.
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10
Citations
35
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Recent Articles
1.
McLeod M, Chang M, Rushin A, Ragavan M, Mahar R, Sharma G, et al.
Cell Rep Med
. 2024 Sep;
5(9):101714.
PMID: 39241774
Metabolic dysfunction-associated steatotic liver disease (MASLD) prevalence is increasing annually and affects over a third of US adults. MASLD can progress to metabolic dysfunction-associated steatohepatitis (MASH), characterized by severe hepatocyte...
2.
Chang M, Staklinski S, Merritt M, Kilberg M
Biol Methods Protoc
. 2023 Nov;
8(1):bpad026.
PMID: 37965492
Human asparagine synthetase (ASNS) catalyzes the conversion of aspartate to asparagine in an ATP-dependent reaction that utilizes glutamine as a nitrogen source while generating glutamate, AMP, and pyrophosphate as additional...
3.
Cai F, Bezwada D, Cai L, Mahar R, Wu Z, Chang M, et al.
Cell Metab
. 2023 Aug;
35(10):1830-1843.e5.
PMID: 37611583
Stable isotopes are powerful tools to assess metabolism. C labeling is detected using nuclear magnetic resonance (NMR) spectroscopy or mass spectrometry (MS). MS has excellent sensitivity but generally cannot discriminate...
4.
Chang M, Staklinski S, Malut V, Pierre G, Kilberg M, Merritt M
Nutrients
. 2023 Apr;
15(8).
PMID: 37111157
The natural amino acid asparagine (Asn) is required by cells to sustain function and proliferation. Healthy cells can synthesize Asn through asparagine synthetase (ASNS) activity, whereas specific cancer and genetically...
5.
Staklinski S, Chang M, Ahrens-Nicklas R, Kaur S, Stefanatos A, Dudenhausen E, et al.
JIMD Rep
. 2023 Mar;
64(2):167-179.
PMID: 36873094
Asparagine synthetase (ASNS) catalyzes the synthesis of asparagine (Asn) from aspartate and glutamine. Biallelic mutations in the gene result in ASNS Deficiency (ASNSD). Children with ASNSD exhibit congenital microcephaly, epileptic-like...
6.
Lei J, Mahar R, Chang M, Collins J, Merritt M, Garrett T, et al.
Anal Chem
. 2023 Jan;
PMID: 36630396
Building an accurate lipid inventory relies on coordinated information from orthogonal analytical capabilities. Integrating the familiar workflow of liquid chromatography (LC), high-resolution mass spectrometry (HRMS), and tandem mass spectrometry (MS/MS)...
7.
Staklinski S, Chang M, Yu F, Collins Ruff K, Franz D, Qian Z, et al.
J Biol Chem
. 2022 Aug;
298(9):102385.
PMID: 35985424
Asparagine synthetase (ASNS) catalyzes synthesis of asparagine (Asn) and Glu from Asp and Gln in an ATP-dependent reaction. Asparagine synthetase deficiency (ASNSD) results from biallelic mutations in the ASNS gene....
8.
Chang M, Mahar R, McLeod M, Giacalone A, Huang X, Boothman D, et al.
Nutrients
. 2022 Jul;
14(15).
PMID: 35893874
The compound β-lapachone, a naturally derived naphthoquinone, has been utilized as a potent medicinal nutrient to improve health. Over the last twelve years, numerous reports have demonstrated distinct associations of...
9.
Mahar R, Ragavan M, Chang M, Hardiman S, Moussatche N, Behar A, et al.
Sci Rep
. 2022 Jul;
12(1):12599.
PMID: 35871072
Oncolytic viral therapy is a recent advance in cancer treatment, demonstrating promise as a primary treatment option. To date, the secondary metabolic effects of viral infection in cancer cells has...
10.
Mahar R, Chang M, Merritt M
Cancers (Basel)
. 2021 Aug;
13(16).
PMID: 34439319
Treatment of cancers with β-lapachone causes NAD(P)H: quinone oxidoreductase 1 (NQO1) to generate an unstable hydroquinone that regenerates itself in a futile cycle while producing reactive oxygen species (ROS) in...