Karlos X Moreno
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Explore the profile of Karlos X Moreno including associated specialties, affiliations and a list of published articles.
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12
Citations
185
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Recent Articles
1.
Moreno K, Harrison C, Merritt M, Kovacs Z, Malloy C, Sherry A
NMR Biomed
. 2017 Mar;
30(6).
PMID: 28272754
The pentose phosphate pathway (PPP) is thought to be upregulated in trauma (to produce excess NADPH) and in cancer (to provide ribose for nucleotide biosynthesis), but simple methods for detecting...
2.
Marco-Rius I, Cao P, von Morze C, Merritt M, Moreno K, Chang G, et al.
Magn Reson Med
. 2016 Mar;
77(4):1419-1428.
PMID: 27017966
Purpose: To develop a specialized multislice, single-acquisition approach to detect the metabolites of hyperpolarized (HP) [2- C]dihydroxyacetone (DHAc) to probe gluconeogenesis in vivo, which have a broad 144 ppm spectral...
3.
Jin E, Moreno K, Wang J, Fidelino L, Merritt M, Sherry A, et al.
NMR Biomed
. 2016 Feb;
29(4):466-74.
PMID: 26836042
The source of hyperpolarized (HP) [(13)C]bicarbonate in the liver during metabolism of HP [1-(13)C]pyruvate is uncertain and likely changes with physiology. Multiple processes including decarboxylation through pyruvate dehydrogenase or pyruvate...
4.
Moreno K, Moore C, Burgess S, Sherry A, Malloy C, Merritt M
Metabolomics
. 2015 Nov;
11(5):1144-1156.
PMID: 26543443
In liver, CO can be generated from [1-C] pyruvate via pyruvate dehydrogenase or anaplerotic entry of pyruvate into the TCA cycle followed by decarboxylation at phosphoenolpyruvate carboxykinase (PEPCK), the malic...
5.
Moreno K, Nasr K, Milne M, Sherry A, Goux W
J Magn Reson
. 2015 Jun;
257:15-23.
PMID: 26037136
Here we report the polarization of the solvent OH protons by SABRE using standard iridium-based catalysts under slightly acidic conditions. Solvent polarization was observed in the presence of a variety...
6.
Moreno K, Satapati S, DeBerardinis R, Burgess S, Malloy C, Merritt M
J Biol Chem
. 2014 Oct;
289(52):35859-67.
PMID: 25352600
Glycogenolysis and gluconeogenesis are sensitive to nutritional state, and the net direction of flux is controlled by multiple enzymatic steps. This delicate balance in the liver is disrupted by a...
7.
Khemtong C, Carpenter N, Lumata L, Merritt M, Moreno K, Kovacs Z, et al.
Magn Reson Med
. 2014 Aug;
74(2):312-9.
PMID: 25168480
Purpose: The diseased myocardium lacks metabolic flexibility and responds to stimuli differently compared with healthy hearts. Here, we report the use of hyperpolarized 13C NMR spectroscopy to detect sudden changes...
8.
Moreno K, Harrison C, Sherry A, Malloy C, Merritt M
J Magn Reson
. 2011 Oct;
213(1):187-91.
PMID: 21974998
Nuclei with long T1s are optimal targets for dynamic nuclear polarization (DNP). Therefore, most of the agents used in metabolic imaging and spectroscopy studies are based on carboxylic acid moieties...
9.
Moreno K, Sabelhaus S, Merritt M, Sherry A, Malloy C
Am J Physiol Heart Circ Physiol
. 2010 Mar;
298(5):H1556-64.
PMID: 20207817
Carbon 13 nuclear magnetic resonance (NMR) isotopomer analysis was used to measure the rates of oxidation of long-chain fatty acids, ketones, and pyruvate to determine the minimum pyruvate concentration ([pyruvate])...
10.
Moreno K, Simanek E
Macromolecules
. 2009 Dec;
41(12):4108-4114.
PMID: 19946610
One-dimensional (1D) and two-dimensional (2D) NMR studies are used to probe the conformation of a melamine dendrimer bearing unique NMR signals from the core to the periphery. Four conceptual anchors...