Matthew D Daugherty
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Explore the profile of Matthew D Daugherty including associated specialties, affiliations and a list of published articles.
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45
Citations
1799
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Recent Articles
21.
Tsu B, Fay E, Nguyen K, Corley M, Hosuru B, Dominguez V, et al.
Front Immunol
. 2021 Nov;
12:769543.
PMID: 34790204
Many pathogens encode proteases that serve to antagonize the host immune system. In particular, viruses with a positive-sense single-stranded RNA genome [(+)ssRNA], including picornaviruses, flaviviruses, and coronaviruses, encode proteases that...
22.
Luscher B, Ahel I, Altmeyer M, Ashworth A, Bai P, Chang P, et al.
FEBS J
. 2021 Jul;
289(23):7399-7410.
PMID: 34323016
ADP-ribosylation, a modification of proteins, nucleic acids, and metabolites, confers broad functions, including roles in stress responses elicited, for example, by DNA damage and viral infection and is involved in...
23.
Sundaramoorthy E, Ryan A, Fulzele A, Leonard M, Daugherty M, Bennett E
J Cell Sci
. 2021 Apr;
134(8).
PMID: 33912921
Viral infection both activates stress signaling pathways and redistributes ribosomes away from host mRNAs to translate viral mRNAs. The intricacies of this ribosome shuffle from host to viral mRNAs are...
24.
Tsu B, Beierschmitt C, Ryan A, Agarwal R, Mitchell P, Daugherty M
Elife
. 2021 Jan;
10.
PMID: 33410748
The NLRP1 inflammasome is a multiprotein complex that is a potent activator of inflammation. Mouse NLRP1B can be activated through proteolytic cleavage by the bacterial Lethal Toxin (LeTx) protease, resulting...
25.
Mudla A, Jiang Y, Arimoto K, Xu B, Rajesh A, Ryan A, et al.
Elife
. 2020 Sep;
9.
PMID: 32945770
Cells use molecular circuits to interpret and respond to extracellular cues, such as hormones and cytokines, which are often released in a temporally varying fashion. In this study, we combine...
26.
Garrigues J, Tsu B, Daugherty M, Pasquinelli A
Elife
. 2019 Dec;
8.
PMID: 31825311
Heat Shock Factor 1 (HSF-1) is a key regulator of the heat shock response (HSR). Upon heat shock, HSF-1 binds well-conserved motifs, called Heat Shock Elements (HSEs), and drives expression...
27.
RNA-binding protein isoforms ZAP-S and ZAP-L have distinct antiviral and immune resolution functions
Schwerk J, Soveg F, Ryan A, Thomas K, Hatfield L, Ozarkar S, et al.
Nat Immunol
. 2019 Nov;
20(12):1610-1620.
PMID: 31740798
The initial response to viral infection is anticipatory, with host antiviral restriction factors and pathogen sensors constantly surveying the cell to rapidly mount an antiviral response through the synthesis and...
28.
Daugherty M, Zanders S
Curr Opin Genet Dev
. 2019 Aug;
58-59:49-54.
PMID: 31466040
Genetic conflicts arise when the evolutionary interests of two genetic elements are not aligned. Conflicts between genomes (e.g. pathogen versus host) or within the same genome (e.g. internal parasitic DNA...
29.
Moens U, Calvignac-Spencer S, Lauber C, Ramqvist T, Feltkamp M, Daugherty M, et al.
J Gen Virol
. 2017 Jun;
98(6):1159-1160.
PMID: 28640744
The Polyomaviridae is a family of small, non-enveloped viruses with circular dsDNA genomes of approximately 5 kbp. The family includes four genera whose members have restricted host range, infecting mammals...
30.
Chavarria-Smith J, Mitchell P, Ho A, Daugherty M, Vance R
PLoS Pathog
. 2016 Dec;
12(12):e1006052.
PMID: 27926929
Inflammasomes are cytosolic multi-protein complexes that initiate immune responses to infection by recruiting and activating the Caspase-1 protease. Human NLRP1 was the first protein shown to form an inflammasome, but...