Patrick S Mitchell
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Explore the profile of Patrick S Mitchell including associated specialties, affiliations and a list of published articles.
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30
Citations
7358
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Recent Articles
1.
Churchill M, Pandeya A, Bauer R, Christopher T, Krug S, Honodel R, et al.
J Exp Med
. 2025 Mar;
222(6).
PMID: 40079814
To distinguish pathogens from commensals, the intestinal epithelium employs cytosolic innate immune sensors. Activation of the NAIP-NLRC4 inflammasome initiates extrusion of infected intestinal epithelial cells (IEC) upon cytosolic bacterial sensing....
2.
Turcotte E, Kim K, Eislmayr K, Goers L, Mitchell P, Lesser C, et al.
bioRxiv
. 2025 Feb;
PMID: 39975412
The NAIP-NLRC4 inflammasome senses pathogenic bacteria by recognizing the cytosolic presence of bacterial proteins such as flagellin and type III secretion system (T3SS) subunits. In mice, the NAIP-NLRC4 inflammasome provides...
3.
Kulsuptrakul J, Emerman M, Mitchell P
bioRxiv
. 2024 Sep;
PMID: 39229127
Our previous work demonstrated that CARD8 detects HIV-1 infection by sensing the enzymatic activity of the HIV protease, resulting in CARD8-dependent inflammasome activation (Kulsuptrakul et al., 2023). CARD8 recognition of...
4.
Tibble R, Yonemitsu M, Mitchell P
J Exp Med
. 2023 Aug;
220(10).
PMID: 37642998
In this issue of JEM, companion articles from Pinilla et al. (2023. J. Exp. Med.https://doi.org/10.1084/jem.20230104) and Robinson et al. (2023. J. Exp. Med.https://doi.org/10.1084/jem.20230105) demonstrate that ribotoxic stress induced by Pseudomonas...
5.
Kroken A, Klein K, Mitchell P, Nieto V, Jedel E, Evans D, et al.
mSphere
. 2023 Aug;
8(5):e0035123.
PMID: 37589460
Pathogenesis of infections can include bacterial survival inside epithelial cells. Previously, we showed that this involves multiple roles played by the type three secretion system (T3SS), and specifically the effector...
6.
Kulsuptrakul J, Turcotte E, Emerman M, Mitchell P
Elife
. 2023 Jul;
12.
PMID: 37417868
Inflammasomes are cytosolic innate immune complexes that assemble upon detection of diverse pathogen-associated cues and play a critical role in host defense and inflammatory pathogenesis. Here, we find that the...
7.
Tsu B, Agarwal R, Gokhale N, Kulsuptrakul J, Ryan A, Fay E, et al.
PLoS Biol
. 2023 Jun;
21(6):e3002144.
PMID: 37289745
Hosts have evolved diverse strategies to respond to microbial infections, including the detection of pathogen-encoded proteases by inflammasome-forming sensors such as NLRP1 and CARD8. Here, we find that the 3CL...
8.
Kroken A, Klein K, Mitchell P, Nieto V, Jedel E, Evans D, et al.
bioRxiv
. 2023 Feb;
PMID: 36824932
Pathogenesis of Pseudomonas aeruginosa infections can include bacterial survival inside epithelial cells. Previously, we showed this involves multiple roles played by the type three-secretion system (T3SS), and specifically the effector...
9.
Tsu B, Agarwal R, Gokhale N, Kulsuptrakul J, Ryan A, Castro L, et al.
bioRxiv
. 2022 Sep;
PMID: 36172130
Hosts have evolved diverse strategies to respond to microbial infections, including the detection of pathogen-encoded proteases by inflammasome-forming sensors such as NLRP1 and CARD8. Here, we find that the 3CL...
10.
Kulsuptrakul J, Mitchell P
Nat Chem Biol
. 2022 Feb;
18(5):439-440.
PMID: 35165444
No abstract available.