Brian V Tsu
Overview
Explore the profile of Brian V Tsu including associated specialties, affiliations and a list of published articles.
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Articles
10
Citations
533
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Recent Articles
1.
Kalluraya C, Weitzel A, Tsu B, Daugherty M
Proc Natl Acad Sci U S A
. 2023 Aug;
120(34):e2310867120.
PMID: 37579166
No abstract available.
2.
Tsu B, Agarwal R, Gokhale N, Kulsuptrakul J, Ryan A, Fay E, et al.
PLoS Biol
. 2023 Jun;
21(6):e3002144.
PMID: 37289745
Hosts have evolved diverse strategies to respond to microbial infections, including the detection of pathogen-encoded proteases by inflammasome-forming sensors such as NLRP1 and CARD8. Here, we find that the 3CL...
3.
Kalluraya C, Weitzel A, Tsu B, Daugherty M
Proc Natl Acad Sci U S A
. 2023 Apr;
120(16):e2214815120.
PMID: 37036996
The vertebrate eye was described by Charles Darwin as one of the greatest potential challenges to a theory of natural selection by stepwise evolutionary processes. While numerous evolutionary transitions that...
4.
Stevens D, Beierschmitt C, Mahesula S, Corley M, Salogiannis J, Tsu B, et al.
Elife
. 2022 Oct;
11.
PMID: 36222652
Viruses interact with the intracellular transport machinery to promote viral replication. Such host-virus interactions can drive host gene adaptation, leaving signatures of pathogen-driven evolution in host genomes. Here, we leverage...
5.
Tsu B, Agarwal R, Gokhale N, Kulsuptrakul J, Ryan A, Castro L, et al.
bioRxiv
. 2022 Sep;
PMID: 36172130
Hosts have evolved diverse strategies to respond to microbial infections, including the detection of pathogen-encoded proteases by inflammasome-forming sensors such as NLRP1 and CARD8. Here, we find that the 3CL...
6.
Tsu B, Fay E, Nguyen K, Corley M, Hosuru B, Dominguez V, et al.
Front Immunol
. 2021 Nov;
12:769543.
PMID: 34790204
Many pathogens encode proteases that serve to antagonize the host immune system. In particular, viruses with a positive-sense single-stranded RNA genome [(+)ssRNA], including picornaviruses, flaviviruses, and coronaviruses, encode proteases that...
7.
Tsu B, Beierschmitt C, Ryan A, Agarwal R, Mitchell P, Daugherty M
Elife
. 2021 Jan;
10.
PMID: 33410748
The NLRP1 inflammasome is a multiprotein complex that is a potent activator of inflammation. Mouse NLRP1B can be activated through proteolytic cleavage by the bacterial Lethal Toxin (LeTx) protease, resulting...
8.
Garrigues J, Tsu B, Daugherty M, Pasquinelli A
Elife
. 2019 Dec;
8.
PMID: 31825311
Heat Shock Factor 1 (HSF-1) is a key regulator of the heat shock response (HSR). Upon heat shock, HSF-1 binds well-conserved motifs, called Heat Shock Elements (HSEs), and drives expression...
9.
Saier Jr M, Reddy V, Tsu B, Ahmed M, Li C, Moreno-Hagelsieb G
Nucleic Acids Res
. 2015 Nov;
44(D1):D372-9.
PMID: 26546518
The Transporter Classification Database (TCDB; http://www.tcdb.org) is a freely accessible reference database for transport protein research, which provides structural, functional, mechanistic, evolutionary and disease/medical information about transporters from organisms of...
10.
Tsu B, Saier Jr M
PLoS One
. 2015 Oct;
10(10):e0137184.
PMID: 26474485
The LysE superfamily consists of transmembrane transport proteins that catalyze export of amino acids, lipids and heavy metal ions. Statistical means were used to show that it includes newly identified...