Martyn P Mahaut-Smith
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Explore the profile of Martyn P Mahaut-Smith including associated specialties, affiliations and a list of published articles.
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46
Citations
751
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Recent Articles
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Wright J, Jones S, Parvathy S, Kaczmarek L, Forsythe I, Farndale R, et al.
Platelets
. 2021 Aug;
33(3):451-461.
PMID: 34348571
Kv1.3 is a voltage-gated K-selective channel with roles in immunity, insulin-sensitivity, neuronal excitability and olfaction. Despite being one of the largest ionic conductances of the platelet surface membrane, its contribution...
3.
Wright J, Mahaut-Smith M
Platelets
. 2021 Apr;
32(7):872-879.
PMID: 33872124
Potassium ions have widespread roles in cellular homeostasis and activation as a consequence of their large outward concentration gradient across the surface membrane and ability to rapidly move through K-selective...
4.
Bye A, Gibbins J, Mahaut-Smith M
Sci Signal
. 2020 Jan;
13(615).
PMID: 31964805
Cells sense extracellular nucleotides through the P2Y class of purinergic G protein-coupled receptors (GPCRs), which stimulate integrin activation through signaling events, including intracellular Ca mobilization. We investigated the relationship between...
5.
Taylor K, Mahaut-Smith M
Platelets
. 2019 Apr;
30(8):962-966.
PMID: 31008669
TMEM16F is a surface membrane protein critical for platelet procoagulant activity, which exhibits both phospholipid scramblase and ion channel activities following sustained elevation of cytosolic Ca. The extent to which...
6.
Ilkan Z, Watson S, Watson S, Mahaut-Smith M
Thromb Haemost
. 2018 Feb;
118(2):369-380.
PMID: 29443373
Platelets express key receptors of the innate immune system such as FcγRIIa and Toll-like receptors (TLR). P2X1 cation channels amplify the platelet responses to several major platelet stimuli, particularly glycoprotein...
7.
Pugh N, Maddox B, Bihan D, Taylor K, Mahaut-Smith M, Farndale R
Thromb Haemost
. 2017 May;
117(8):1588-1600.
PMID: 28536721
The platelet receptors glycoprotein (Gp)VI, integrin αβ and GpIb/V/IX mediate platelet adhesion and activation during thrombogenesis. Increases of intracellular Ca ([Ca]) are key signals during platelet activation; however, their relative...
8.
Ilkan Z, Wright J, Goodall A, Gibbins J, Jones C, Mahaut-Smith M
J Biol Chem
. 2017 Apr;
292(22):9204-9217.
PMID: 28416610
The role of mechanosensitive (MS) Ca-permeable ion channels in platelets is unclear, despite the importance of shear stress in platelet function and life-threatening thrombus formation. We therefore sought to investigate...
9.
Wright J, Amisten S, Goodall A, Mahaut-Smith M
Thromb Haemost
. 2016 Jun;
116(2):272-84.
PMID: 27277069
Ion channels have crucial roles in all cell types and represent important therapeutic targets. Approximately 20 ion channels have been reported in human platelets; however, no systematic study has been...
10.
Mahaut-Smith M, Taylor K, Evans R
Adv Exp Med Biol
. 2016 May;
898:305-29.
PMID: 27161234
Ligand-gated ion channels on the cell surface are directly activated by the binding of an agonist to their extracellular domain and often referred to as ionotropic receptors. P2X receptors are...