Joy R Wright
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Explore the profile of Joy R Wright including associated specialties, affiliations and a list of published articles.
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10
Citations
147
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Recent Articles
1.
Owen M, Wright J, Tuddenham E, King J, Goodall A, Dunster J
J Thromb Haemost
. 2024 Mar;
22(6):1689-1703.
PMID: 38521192
Background: Mathematical models of coagulation have been developed to mirror thrombin generation in plasma, with the aim of investigating how variation in coagulation factor levels regulates hemostasis. However, current models...
2.
Wright J, Deen Q, Stevenson A, Telford-Cooke L, Parker C, Martin-Ruiz C, et al.
J Alzheimers Dis
. 2022 Sep;
89(4):1483-1492.
PMID: 36057826
Background: Myeloperoxidase (MPO), a neutrophil-derived pro-inflammatory protein, co-localizes with amyloid-β (Aβ) plaques in Alzheimer's disease (AD). Anti-dementia treatment may facilitate efflux of Aβ and associated plaque proteins from the brain...
3.
Dunster J, Wright J, Samani N, Goodall A
Front Cardiovasc Med
. 2022 Jul;
9:919394.
PMID: 35845083
Introduction: Advancing understanding of key factors that determine the magnitude of the hemostatic response may facilitate the identification of individuals at risk of generating an occlusive thrombus as a result...
4.
Wright J, Chauhan M, Shah C, Ring A, Thomas A, Goodall A, et al.
JACC CardioOncol
. 2021 Aug;
2(2):236-250.
PMID: 34396233
Background: In cancer, platelets may facilitate metastatic spread by a number of mechanisms as well as contribute to thrombotic complications. Ticagrelor, a platelet antagonist- that blocks adenosine diphosphate activation of...
5.
Wright J, Jones S, Parvathy S, Kaczmarek L, Forsythe I, Farndale R, et al.
Platelets
. 2021 Aug;
33(3):451-461.
PMID: 34348571
Kv1.3 is a voltage-gated K-selective channel with roles in immunity, insulin-sensitivity, neuronal excitability and olfaction. Despite being one of the largest ionic conductances of the platelet surface membrane, its contribution...
6.
Wright J, Mahaut-Smith M
Platelets
. 2021 Apr;
32(7):872-879.
PMID: 33872124
Potassium ions have widespread roles in cellular homeostasis and activation as a consequence of their large outward concentration gradient across the surface membrane and ability to rapidly move through K-selective...
7.
Ilkan Z, Wright J, Goodall A, Gibbins J, Jones C, Mahaut-Smith M
J Biol Chem
. 2017 Apr;
292(22):9204-9217.
PMID: 28416610
The role of mechanosensitive (MS) Ca-permeable ion channels in platelets is unclear, despite the importance of shear stress in platelet function and life-threatening thrombus formation. We therefore sought to investigate...
8.
Wright J, Amisten S, Goodall A, Mahaut-Smith M
Thromb Haemost
. 2016 Jun;
116(2):272-84.
PMID: 27277069
Ion channels have crucial roles in all cell types and represent important therapeutic targets. Approximately 20 ion channels have been reported in human platelets; however, no systematic study has been...
9.
Taylor K, Wright J, Mahaut-Smith M
Biochem Soc Trans
. 2015 May;
43(3):502-7.
PMID: 26009198
Pannexin-1 (Panx1) forms anion-selective channels with a permeability up to 1 kDa and represents a pathway for the release of cytosolic ATP. Several structurally similar connexin (Cx) proteins have been...
10.
Vaiyapuri S, Jones C, Sasikumar P, Moraes L, Munger S, Wright J, et al.
Circulation
. 2012 Apr;
125(20):2479-91.
PMID: 22528526
Background: Connexins are a widespread family of membrane proteins that assemble into hexameric hemichannels, also known as connexons. Connexons regulate membrane permeability in individual cells or couple between adjacent cells...