Melanie Verreault
Overview
Explore the profile of Melanie Verreault including associated specialties, affiliations and a list of published articles.
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26
Citations
316
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Recent Articles
1.
Gagnon W, Garneau V, Trottier J, Verreault M, Couillard C, Roy D, et al.
Nutrients
. 2022 Sep;
14(18).
PMID: 36145234
Cholesterol-derived bile acids (BAs) affect numerous physiological functions such as glucose homeostasis, lipid metabolism and absorption, intestinal inflammation and immunity, as well as intestinal microbiota diversity. Diet influences the composition...
2.
Grosse L, Chouinard S, Paquet S, Verreault M, Trottier J, Belanger A, et al.
Biology (Basel)
. 2022 Mar;
11(3).
PMID: 35336777
Glucuronidation, catalyzed by UDP-glucuronosyltransferase UGT2B enzymes, is a major inactivating and elimination pathway for androgen hormones in humans. Whether Ugt2b enzymes from mice are also reactive with these hormones have...
3.
Mennillo E, Yang X, Weber A, Maruo Y, Verreault M, Barbier O, et al.
Drug Metab Dispos
. 2021 Oct;
50(1):33-42.
PMID: 34697081
The human UDP-glucuronosyltransferases (UGTs) represent an important family of drug-metabolizing enzymes, with UGT1A1 targeting the conjugation and detoxification of many exogenous substances, including pharmaceutical drugs. In this study we generated...
4.
Therien A, Cieslak A, Verreault M, Perreault M, Trottier J, Gobeil S, et al.
Nutrients
. 2021 Aug;
13(8).
PMID: 34444777
Ursodeoxycholic acid (UDCA) is the first line therapy for the treatment of cholestatic and autoimmune liver diseases. Its clinical use is currently limited by a significant proportion of non-responder patients....
5.
Bosoi C, Vandal M, Tournissac M, Leclerc M, Fanet H, Mitchell P, et al.
Hepatol Commun
. 2021 Mar;
5(3):446-460.
PMID: 33681678
Obesity and diabetes are strongly associated not only with fatty liver but also cognitive dysfunction. Moreover, their presence, particularly in midlife, is recognized as a risk factor for Alzheimer's disease...
6.
Hansmann E, Mennillo E, Yoda E, Verreault M, Barbier O, Chen S, et al.
Drug Metab Dispos
. 2020 Jan;
48(4):255-263.
PMID: 31980500
Liver X receptors (LXRs), LXR and LXR, are nuclear receptors that regulate the metabolism of cholesterol and bile acids and are activated by oxysterols. Humanized () mice express the 9-human...
7.
Perreault M, Wunsch E, Bialek A, Trottier J, Verreault M, Caron P, et al.
Can J Gastroenterol Hepatol
. 2018 Jun;
2018:8096314.
PMID: 29850459
Biliary obstruction, a severe cholestatic complication, causes accumulation of toxic bile acids (BAs) in liver cells. Glucuronidation, catalyzed by UDP-glucuronosyltransferase (UGT) enzymes, detoxifies cholestatic BAs. Using liquid chromatography coupled to...
8.
Cieslak A, Trottier J, Verreault M, Milkiewicz P, Vohl M, Barbier O
Can J Gastroenterol Hepatol
. 2018 Jun;
2018:6031074.
PMID: 29850457
Cholestasis is characterized by the accumulation of toxic bile acids (BAs) in liver cells. The present study aimed to evaluate the effects of n-3 polyunsaturated fatty acids (n-3 PUFAs), such...
9.
Li H, Xie N, Chen R, Verreault M, Fazli L, Gleave M, et al.
Cancer Res
. 2016 Sep;
76(22):6701-6711.
PMID: 27659047
Castration-resistant prostate cancer (CRPC) is characterized by a shift in androgen receptor (AR) signaling from androgen-dependent to androgen (ligand)-independent. UDP-glucuronosyltransferase 2B17 (UGT2B17) is a key enzyme that maintains androgen homeostasis...
10.
Cieslak A, Kelly I, Trottier J, Verreault M, Wunsch E, Milkiewicz P, et al.
Proteomics
. 2016 Sep;
16(21):2827-2837.
PMID: 27634100
This study aimed at establishing a sensitive multiple reaction monitoring-mass spectrometry (MRM-MS) method for the quantification of the drug metabolizing cytochrome P450 (CYP)3A4 enzyme in human liver homogenates. Liver samples...