Ann Marshak-Rothstein
Overview
Explore the profile of Ann Marshak-Rothstein including associated specialties, affiliations and a list of published articles.
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107
Citations
5883
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Recent Articles
1.
Hao K, Marshak-Rothstein A
Curr Opin Immunol
. 2025 Jan;
93:102535.
PMID: 39889356
The key role of nucleic acid sensing receptors in the development of autoimmune and autoinflammatory diseases is becoming increasingly apparent. Activation of these sensors has been attributed to the failure...
2.
Hao K, Gao K, Strauss M, Subramanian S, Marshak-Rothstein A
bioRxiv
. 2024 Jul;
PMID: 39071327
Patients with biallelic hypomorphic mutation in develop systemic autoinflammation and early-onset liver fibrosis. Prior studies showed that Dnase2 Ifnar double knockout (DKO) mice develop Type I IFN-independent liver inflammation, but...
3.
Cancro M, Marshak-Rothstein A
Nat Immunol
. 2024 Jul;
25(9):1522-1523.
PMID: 39060649
No abstract available.
4.
Gao K, Chiang K, Subramanian S, Yin X, Utz P, Nundel K, et al.
JCI Insight
. 2024 Jul;
9(16).
PMID: 39024563
Gain-of-function mutations in the dsDNA sensing adaptor STING lead to a severe autoinflammatory syndrome known as STING-associated vasculopathy with onset in infancy (SAVI). Patients with SAVI develop interstitial lung disease...
5.
Guo Y, Verma B, Shrestha M, Marshak-Rothstein A, Gregory-Ksander M
Res Sq
. 2024 Jul;
PMID: 38947028
Background-: Glaucoma is a complex multifactorial disease where apoptosis and inflammation represent two key pathogenic mechanisms. However, the relative contribution of apoptosis versus inflammation in axon degeneration and death of...
6.
Koirala A, Marshak-Rothstein A, Ksander B, Gregory-Ksander M
Res Sq
. 2024 May;
PMID: 38766158
Neovascular age-related macular degeneration (AMD), results from choroidal neovascularization (CNV), retinal edema and loss of photoreceptors. Previous studies suggested that Fas Ligand (FasL) on retinal pigment epithelial cells inhibited CNV...
7.
Gao K, Chiang K, Jiang Z, Korkmaz F, Janardhan H, Trivedi C, et al.
Cell Rep
. 2024 Apr;
43(4):114114.
PMID: 38625791
Patients afflicted with Stimulator of interferon gene (STING) gain-of-function mutations frequently present with debilitating interstitial lung disease (ILD) that is recapitulated in mice expressing the STING mutation (VM). Prior radiation...
8.
Cakan E, Ah Kioon M, Garcia-Carmona Y, Glauzy S, Oliver D, Yamakawa N, et al.
J Exp Med
. 2023 Sep;
220(12).
PMID: 37773045
Central B cell tolerance is believed to be regulated by B cell receptor signaling induced by the recognition of self-antigens in immature B cells. Using humanized mice with defective MyD88,...
9.
Raso F, Liu S, Simpson M, Barton G, Mayer C, Acharya M, et al.
Immunity
. 2023 Sep;
56(10):2373-2387.e8.
PMID: 37714151
Immunoglobulin A (IgA) maintains commensal communities in the intestine while preventing dysbiosis. IgA generated against intestinal microbes assures the simultaneous binding to multiple, diverse commensal-derived antigens. However, the exact mechanisms...
10.
Gavin A, Blane T, Thinnes T, Gerlt E, Marshak-Rothstein A, Huang D, et al.
Immunohorizons
. 2023 Aug;
7(8):577-586.
PMID: 37555846
Phospholipase D4 (PLD4) is an endolysosomal exonuclease of ssRNA and ssDNA, rather than a phospholipase as its name suggests. Human polymorphisms in the PLD4 gene have been linked by genome-wide...