Steven H Kleinstein
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Explore the profile of Steven H Kleinstein including associated specialties, affiliations and a list of published articles.
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189
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8614
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Recent Articles
1.
Olaloye O, Gu W, Gehlhaar A, Sabuwala B, Eke C, Li Y, et al.
Sci Transl Med
. 2025 Mar;
17(788):eadr0942.
PMID: 40043141
Extremely premature infants (EPIs) who are born before 30 weeks of gestation are susceptible to infection; however, the trajectory of their peripheral immunity is poorly understood. Here, we undertook longitudinal...
2.
Jayavelu N, Samaha H, Wimalasena S, Hoch A, Gygi J, Gabernet G, et al.
medRxiv
. 2025 Feb;
PMID: 39990570
The post-acute sequelae of SARS-CoV-2 (PASC), also known as long COVID, remain a significant health issue that is incompletely understood. Predicting which acutely infected individuals will go on to develop...
3.
Gabernet G, Maciuch J, Gygi J, Moore J, Hoch A, Syphurs C, et al.
bioRxiv
. 2025 Feb;
PMID: 39990442
Following SARS-CoV-2 infection, ~10-35% of COVID-19 patients experience long COVID (LC), in which often debilitating symptoms persist for at least three months. Elucidating the biologic underpinnings of LC could identify...
4.
Mattessich M, Reyna J, Aron E, Ay F, Kilmer M, Kleinstein S, et al.
Bioinformatics
. 2025 Jan;
41(1).
PMID: 39799512
Summary: With the increased reliance on multi-omics data for bulk and single-cell analyses, the availability of robust approaches to perform unsupervised learning for clustering, visualization, and feature selection is imperative....
5.
Pickering H, Schaenman J, Phan H, Maguire C, Tsitsiklis A, Rouphael N, et al.
Nat Commun
. 2025 Jan;
16(1):586.
PMID: 39794319
Coronavirus disease 2019 (COVID-19) poses significant risks for solid organ transplant recipients, who have atypical but poorly characterized immune responses to infection. We aim to understand the host immunologic and...
6.
Wang K, Nie Y, Maguire C, Syphurs C, Sheen H, Karoly M, et al.
bioRxiv
. 2024 Dec;
PMID: 39651165
Hospitalized COVID-19 patients exhibit diverse immune responses during acute infection, which are associated with a wide range of clinical outcomes. However, understanding these immune heterogeneities and their links to various...
7.
Maguire C, Chen J, Rouphael N, Pickering H, Phan H, Glascock A, et al.
bioRxiv
. 2024 Nov;
PMID: 39605478
Chronic viral infections are ubiquitous in humans, with individuals harboring multiple latent viruses that can reactivate during acute illnesses. Recent studies have suggested that SARS-CoV-2 infection can lead to reactivation...
8.
Shinde P, Willemsen L, Anderson M, Aoki M, Basu S, Burel J, et al.
bioRxiv
. 2024 Sep;
PMID: 39282381
Systems vaccinology studies have been used to build computational models that predict individual vaccine responses and identify the factors contributing to differences in outcome. Comparing such models is challenging due...
9.
Coelho C, Marquez S, Nguemwo Tentokam B, Berhe A, Miura K, Rao V, et al.
NPJ Vaccines
. 2024 Aug;
9(1):144.
PMID: 39127706
The impact of adjuvants on malaria vaccine-induced antibody repertoire is poorly understood. Here, we characterize the impact of two adjuvants, Alhydrogel® and AS01, on antibody clonotype diversity, binding and function,...
10.
Fantin R, Clark J, Cohn H, Jaiswal D, Bozarth B, Civljak A, et al.
bioRxiv
. 2024 Jul;
PMID: 39071292
The emergence of highly contagious and immune-evasive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants has required reformulation of coronavirus disease 2019 (COVID-19) vaccines to target those new variants specifically....