Mark J Mulvihill
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Explore the profile of Mark J Mulvihill including associated specialties, affiliations and a list of published articles.
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34
Citations
435
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Recent Articles
1.
Muralidharan C, Huang F, Enriquez J, Wang J, Nelson J, Nargis T, et al.
bioRxiv
. 2024 Jun;
PMID: 38895427
Preventing the onset of autoimmune type 1 diabetes (T1D) is feasible through pharmacological interventions that target molecular stress-responsive mechanisms. Cellular stresses, such as nutrient deficiency, viral infection, or unfolded proteins,...
2.
Muralidharan C, Huang F, Enriquez J, Wang J, Nelson J, Nargis T, et al.
J Clin Invest
. 2024 Jun;
134(16).
PMID: 38889047
Preventing the onset of autoimmune type 1 diabetes (T1D) is feasible through pharmacological interventions that target molecular stress-responsive mechanisms. Cellular stresses, such as nutrient deficiency, viral infection, or unfolded proteins,...
3.
Stokes M, Calvo V, Fujisawa S, Dudgeon C, Huang S, Ballal N, et al.
Clin Cancer Res
. 2023 Sep;
29(23):4870-4882.
PMID: 37733811
Purpose: Tumors activate protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK, also called EIF2AK3) in response to hypoxia and nutrient deprivation as a stress-mitigation strategy. Here, we tested the hypothesis...
4.
Stokes M, Surman M, Calvo V, Surguladze D, Li A, Gasparek J, et al.
Pharmaceutics
. 2022 Oct;
14(10).
PMID: 36297668
The protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) is one of three endoplasmic reticulum (ER) transmembrane sensors of the unfolded protein response (UPR) responsible for regulating protein synthesis and...
5.
Calvo V, Surguladze D, Li A, Surman M, Malibhatla S, Bandaru M, et al.
Bioorg Med Chem Lett
. 2021 Apr;
43:128058.
PMID: 33895276
The protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) is one of the three endoplasmic reticulum (ER) transmembrane sensors of the unfolded protein response (UPR) that regulates protein synthesis, alleviates...
6.
Veerman J, Bruseker Y, Damen E, Heijne E, van Bruggen W, Hekking K, et al.
ACS Med Chem Lett
. 2021 Apr;
12(4):555-562.
PMID: 33859795
Herein we report the discovery of 2,4-1-imidazole carboxamides as novel, biochemically potent, and kinome selective inhibitors of transforming growth factor β-activated kinase 1 (TAK1). The target was subjected to a...
7.
Marcaurelle L, Mulvihill M
ACS Cent Sci
. 2016 Jul;
2(6):367-9.
PMID: 27413779
No abstract available.
8.
Jin M, Buck E, Mulvihill M
Oncol Rev
. 2015 May;
7(1):e3.
PMID: 25992224
Based on over three decades of pre-clinical data, insulin-like growth factor-1 receptor (IGF-1R) signaling has gained recognition as a promoter of tumorogenesis, driving cell survival and proliferation in multiple human...
9.
Jin M, Petronella B, Cooke A, Kadalbajoo M, Siu K, Kleinberg A, et al.
ACS Med Chem Lett
. 2014 Jun;
4(7):627-31.
PMID: 24900721
This letter describes a series of small molecule inhibitors of IGF-1R with unique time-dependent binding kinetics and slow off-rates. Structure-activity and structure-kinetic relationships were elucidated and guided further optimizations within...
10.
Jin M, Gokhale P, Cooke A, Foreman K, Buck E, May E, et al.
ACS Med Chem Lett
. 2014 Jun;
1(9):510-5.
PMID: 24900240
This report describes the investigation of a series of 5,7-disubstituted imidazo[5,1-f][1,2,4]triazine inhibitors of insulin-like growth factor-1 receptor (IGF-1R) and insulin receptor (IR). Structure-activity relationship exploration and optimization leading to the...